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FTI-277
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Catalog No. T62675Cas No. 170006-73-2
Alias FTI277, FTI 277
FTI-277 hydrochloride is a farnesyl transferase inhibitor and highly potent Ras CAAX peptidomimetic that antagonizes both H-Ras and K-Ras oncogenic signaling pathways, FTI-277 hydrochloride additionally inhibits hepatitis delta virus infection, making it a valuable compound for studying Ras-driven oncogenesis, protein prenylation, and antiviral intervention strategies.
FTI-277
Copy Product Info😃Good
Catalog No. T62675Alias FTI277, FTI 277Cas No. 170006-73-2
FTI-277 hydrochloride is a farnesyl transferase inhibitor and highly potent Ras CAAX peptidomimetic that antagonizes both H-Ras and K-Ras oncogenic signaling pathways, FTI-277 hydrochloride additionally inhibits hepatitis delta virus infection, making it a valuable compound for studying Ras-driven oncogenesis, protein prenylation, and antiviral intervention strategies.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $2,140 | 7-10 days | 7-10 days | |
| 50 mg | $2,785 | 7-10 days | 7-10 days | |
| 100 mg | $3,520 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | FTI-277 hydrochloride is a farnesyl transferase inhibitor and highly potent Ras CAAX peptidomimetic that antagonizes both H-Ras and K-Ras oncogenic signaling pathways, FTI-277 hydrochloride additionally inhibits hepatitis delta virus infection, making it a valuable compound for studying Ras-driven oncogenesis, protein prenylation, and antiviral intervention strategies. |
| In vitro | In HeLa cells expressing the 24-kDa FGF2 isoform, treatment with FTI-277 (20 μM, 48 h) prior to irradiation decreased cell survival by stimulating postmitotic cell death and reducing G2/M-phase arrest, with no impact on control cells lacking the isoform [1]. |
| Synonyms | FTI277, FTI 277 |
| Molecular Weight | 447.61 |
| Formula | C22H29N3O3S2 |
| Cas No. | 170006-73-2 |
| Smiles | C(N[C@@H](CCSC)C(OC)=O)(=O)C1=C(C=C(NC[C@H](CS)N)C=C1)C2=CC=CC=C2 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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