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TJ08 is a 1,2,5-trisubstituted benzimidazole derivative with anticancer properties that effectively induces G1/S phase blockade while promoting apoptotic effects in a variety of cancer cells.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $238 | - | In Stock | |
| 5 mg | $582 | - | In Stock | |
| 10 mg | $708 | - | In Stock | |
| 25 mg | $948 | - | In Stock |
| Description | TJ08 is a 1,2,5-trisubstituted benzimidazole derivative with anticancer properties that effectively induces G1/S phase blockade while promoting apoptotic effects in a variety of cancer cells. |
| In vitro | TJ08 (1-10 μM; 24 hours) induces apoptosis by altering mitochondrial membrane potential, triggering S-phase arrest, halting cancer cell progression, and causing upregulation of caspase activation and downregulation of anti-apoptotic BCl2 protein [1]. |
| Molecular Weight | 405.38 |
| Formula | C22H16FN3O4 |
| Cas No. | 2924274-19-9 |
| Smiles | O=C(C1=CC=C2C(N=C(N2CC3=CC=CC=C3)C4=CC([N+]([O-])=O)=C(F)C=C4)=C1)OC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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