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QN523
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Catalog No. T64374Cas No. 878581-60-3
QN523 represents a novel scaffold with drug-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 shows significant in vivo efficacy in a pancreatic cancer xenograft model. Autophagy is a major mechanism of action.
QN523
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Purity: 99.83%
Catalog No. T64374Cas No. 878581-60-3
QN523 represents a novel scaffold with drug-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 shows significant in vivo efficacy in a pancreatic cancer xenograft model. Autophagy is a major mechanism of action.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $35 | In Stock | In Stock | |
| 10 mg | $59 | In Stock | In Stock | |
| 25 mg | $108 | In Stock | In Stock | |
| 50 mg | $163 | In Stock | In Stock | |
| 100 mg | $247 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.83%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | QN523 represents a novel scaffold with drug-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 shows significant in vivo efficacy in a pancreatic cancer xenograft model. Autophagy is a major mechanism of action. |
| In vitro | QN523 showed significant cytotoxicity with IC50 values ranging from 0.1 to 5.7 μM across 12 cell lines. QN523 at 0.5 μM and gemcitabine at 0.1 μM arrested MIA PaCa-2 cells in the S-phase following 24 and 48 h treatment[1]. |
| In vivo | In NOD/SCID mice of MIA PaCa-2 xenografts, QN523 at 10 mg/kg (intraperitoneal administration) shows no significant delay in tumor growth from day 1 to day 9. QN523 at 20 mg/kg from day 10 and continued until day 44 delayed growth of the MIA PaCa-2 xenograft starting from day 17. On day 44 80% inhibition of tumor growth was observed. No symptoms of gross toxicity such as weakness, weight loss or lethargy were observed in the QN523 treatment group[1]. |
| Molecular Weight | 250.26 |
| Formula | C14H10N4O |
| Cas No. | 878581-60-3 |
| Smiles | O=C(Nc1cccc2cccnc12)c1cnccn1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 16.2 mg/mL (64.73 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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