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Neticonazole

Name: Neticonazole
Brand: TargetMol
SKU: T35335
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35335Cas No. 130726-68-0

Alias SS-717, SS717, SS 717

Neticonazole (SS717) is an imidazole derivative with antifungal activity that inhibits exosome secretion. Neticonazole has anti-infective and anti-cancer effects, can induce contact dermatitis, and can be used to study skin Candida albicans infections.

Neticonazole

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Purity: 99.58%

Catalog No. T35335Alias SS-717, SS717, SS 717Cas No. 130726-68-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$33	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$73	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.58%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Neticonazole (SS717) is an imidazole derivative with antifungal activity that inhibits exosome secretion. Neticonazole has anti-infective and anti-cancer effects, can induce contact dermatitis, and can be used to study skin Candida albicans infections.
Targets&IC50	Exosome:
In vitro	Neticonazole against 39 T. rubrum isolates (MIC80, 0.125 μg/ml) and 28 T. mentagrophytes isolates (MIC80, 0.25 μg/ml). Neticonazole against 39 T. rubrum isolates (MFC80, 0.25 μg/ml) and 28 T. mentagrophytes isolates (MFC 80, 0.25 μg/ml). [1]
In vivo	A clinical isolate of C. albicans, isolate KC-36, was used for production of experimental cutaneous candidiasis in guinea pigs. The MICs of Neticonazole for the test strain were 0.0625. [1]
Synonyms	SS-717, SS717, SS 717

Chemical Properties

Molecular Weight	302.43
Formula	C₁₇H₂₂N₂OS
Cas No.	130726-68-0
Smiles	C(=C\SC)(\C1=C(OCCCCC)C=CC=C1)/N2C=CN=C2

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1M HCl: 80 mg/mL (264.52 mM), when pH is adjusted to 1 with 1M HCl.Sonication is recommended.

DMSO: 200 mg/mL (661.31 mM), Sonication is recommended.

Solution Preparation Table

1M HCl/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3066 mL	16.5328 mL	33.0655 mL	165.3275 mL
5 mM	0.6613 mL	3.3066 mL	6.6131 mL	33.0655 mL
10 mM	0.3307 mL	1.6533 mL	3.3066 mL	16.5328 mL
20 mM	0.1653 mL	0.8266 mL	1.6533 mL	8.2664 mL
50 mM	0.0661 mL	0.3307 mL	0.6613 mL	3.3066 mL
100 mM	0.0331 mL	0.1653 mL	0.3307 mL	1.6533 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc