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Neticonazole

🥰Excellent
Catalog No. T35335Cas No. 130726-68-0
Alias SS-717, SS717, SS 717

Neticonazole (SS717) is an imidazole derivative with antifungal activity that inhibits exosome secretion. Neticonazole has anti-infective and anti-cancer effects, can induce contact dermatitis, and can be used to study skin Candida albicans infections.

Neticonazole
Other Forms of Neticonazole:
Neticonazole HydrochlorideT4985130773-02-3
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Neticonazole

🥰Excellent
Purity: 99.58%
Catalog No. T35335Alias SS-717, SS717, SS 717Cas No. 130726-68-0
Neticonazole (SS717) is an imidazole derivative with antifungal activity that inhibits exosome secretion. Neticonazole has anti-infective and anti-cancer effects, can induce contact dermatitis, and can be used to study skin Candida albicans infections.
Pack SizePriceAvailabilityQuantity
5 mg$33In Stock
1 mL x 10 mM (in DMSO)$73In Stock
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Purity:99.58%
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Product Introduction

Bioactivity
Description
Neticonazole (SS717) is an imidazole derivative with antifungal activity that inhibits exosome secretion. Neticonazole has anti-infective and anti-cancer effects, can induce contact dermatitis, and can be used to study skin Candida albicans infections.
Targets&IC50
Exosome:
In vitro
Neticonazole against 39 T. rubrum isolates (MIC80, 0.125 μg/ml) and 28 T. mentagrophytes isolates (MIC80, 0.25 μg/ml). Neticonazole against 39 T. rubrum isolates (MFC80, 0.25 μg/ml) and 28 T. mentagrophytes isolates (MFC 80, 0.25 μg/ml). [1]
In vivo
A clinical isolate of C. albicans, isolate KC-36, was used for production of experimental cutaneous candidiasis in guinea pigs. The MICs of Neticonazole for the test strain were 0.0625. [1]
SynonymsSS-717, SS717, SS 717
Chemical Properties
Molecular Weight302.43
FormulaC17H22N2OS
Cas No.130726-68-0
SmilesC(=C\SC)(\C1=C(OCCCCC)C=CC=C1)/N2C=CN=C2
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
1M HCl: 80 mg/mL (264.52 mM), when pH is adjusted to 1 with 1M HCl.Sonication is recommended.
DMSO: 200 mg/mL (661.31 mM), Sonication is recommended.
Solution Preparation Table
1M HCl/DMSO
1mg5mg10mg50mg
1 mM3.3066 mL16.5328 mL33.0655 mL165.3275 mL
5 mM0.6613 mL3.3066 mL6.6131 mL33.0655 mL
10 mM0.3307 mL1.6533 mL3.3066 mL16.5328 mL
20 mM0.1653 mL0.8266 mL1.6533 mL8.2664 mL
50 mM0.0661 mL0.3307 mL0.6613 mL3.3066 mL
100 mM0.0331 mL0.1653 mL0.3307 mL1.6533 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

Neticonazolefungal
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