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Prostaglandin E3

Name: Prostaglandin E3
Brand: TargetMol
SKU: T38194
Price: 1590 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38194Cas No. 802-31-3

Alias PGE3

Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, inhibits polarization to M1 macrophages, and shows anti-proliferative effects in human lung cancer cells.

Prostaglandin E3

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Purity: 98%

Catalog No. T38194Alias PGE3Cas No. 802-31-3

Pack Size	Price	USA Warehouse	Global Warehouse
100 μg	$1,590	-	In Stock
500 μg	$4,650	35 days	35 days
1 mg	$6,930	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98%

Appearance:Liquid

Color:Transparent

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Product Introduction

Bioactivity

Description	Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, inhibits polarization to M1 macrophages, and shows anti-proliferative effects in human lung cancer cells.
In vitro	METHODS: To investigate the role of Prostaglandin E3 in modulating macrophage polarization, THP-1 cells (a human monocytic cell line) were used to induce macrophage polarization, and the effects of different concentrations of Prostaglandin E3 on the markers of M1 and M2 macrophages were observed. RESULTS: Prostaglandin E3 (1-10000 nM) was found to inhibit the expression of M1 macrophage markers while promoting the polarization towards M2 macrophages[1].
In vivo	METHODS: To investigate the effect of Prostaglandin E3 on the proliferation of prostate tumor cells, prostate tumor cells were injected into mice, and Prostaglandin E3 was continuously administered during the experiment to observe the growth of the tumors and the infiltration of macrophages. RESULTS: Continuous injection of Prostaglandin E3 (1 µmol/L; every 3 days for 4 weeks) significantly reduced the weight of the transplanted tumors and decreased the expression of CD68 and CD206 (markers of M2 macrophages) within the tumors[1].
Synonyms	PGE3

Chemical Properties

Molecular Weight	350.45
Formula	C₂₀H₃₀O₅
Cas No.	802-31-3
Smiles	C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](C/C=C\CC)O)[C@H](O)CC1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (85.6 mM), Sonication is recommended.

DMF: 30 mg/mL (85.6 mM), Sonication is recommended.

Ethanol: 30 mg/mL (85.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8535 mL	14.2674 mL	28.5347 mL	142.6737 mL
5 mM	0.5707 mL	2.8535 mL	5.7069 mL	28.5347 mL
10 mM	0.2853 mL	1.4267 mL	2.8535 mL	14.2674 mL
20 mM	0.1427 mL	0.7134 mL	1.4267 mL	7.1337 mL
50 mM	0.0571 mL	0.2853 mL	0.5707 mL	2.8535 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc