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GPX4-IN-5

Name: GPX4-IN-5
Brand: TargetMol
SKU: T77755
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77755Cas No. 2922824-09-5

GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces ferroptosis and can be used for the prevention and treatment of triple-negative breast cancer (TNBC).

GPX4-IN-5

🥰Excellent

Purity: 99.58%

Catalog No. T77755Cas No. 2922824-09-5

Pack Size	Price	Availability
1 mg	$45	In Stock
5 mg	$106	In Stock
10 mg	$168	In Stock
25 mg	$283	In Stock
50 mg	$419	In Stock
100 mg	$612	In Stock
200 mg	$867	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock

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Batch Information

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Purity:99.58%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces ferroptosis and can be used for the prevention and treatment of triple-negative breast cancer (TNBC).
Targets&IC50	GPX4:0.12 μM

Chemical Properties

Molecular Weight	381.78
Formula	C₁₈H₁₇ClFNO₅
Cas No.	2922824-09-5
Smiles	O=C(N(C1=CC=C2OCCOC2=C1)C3=CC(OC)=C(F)C(OC)=C3)CCl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (209.54 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6193 mL	13.0965 mL	26.1931 mL	130.9655 mL
5 mM	0.5239 mL	2.6193 mL	5.2386 mL	26.1931 mL
10 mM	0.2619 mL	1.3097 mL	2.6193 mL	13.0965 mL
20 mM	0.1310 mL	0.6548 mL	1.3097 mL	6.5483 mL
50 mM	0.0524 mL	0.2619 mL	0.5239 mL	2.6193 mL
100 mM	0.0262 mL	0.1310 mL	0.2619 mL	1.3097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc