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Azide-PEG3-Desthiobiotin

Name: Azide-PEG3-Desthiobiotin
Brand: TargetMol
SKU: T38888
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38888Cas No. 1426828-06-9

Alias Azide-PEG3-Desthiobiotin

Azide-PEG3-Desthiobiotin is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Azide-PEG3-Desthiobiotin

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Purity: 99.27%

Catalog No. T38888Alias Azide-PEG3-DesthiobiotinCas No. 1426828-06-9

Azide-PEG3-Desthiobiotin is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$272	-	In Stock
50 mg	$438	-	In Stock
100 mg	$658	-	In Stock
500 mg	$1,380	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.27%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Azide-PEG3-Desthiobiotin is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
In vitro	PROTACs, comprising two distinct ligands connected by a linker—one ligand for an E3 ubiquitin ligase and the other for the target protein—exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. [1]
Synonyms	Azide-PEG3-Desthiobiotin

Chemical Properties

Molecular Weight	414.5
Formula	C₁₈H₃₄N₆O₅
Cas No.	1426828-06-9
Smiles	C(CCCCC(NCCOCCOCCOCCN=[N+]=[N-])=O)[C@@H]1[C@H](C)NC(=O)N1

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (241.25 mM), Sonication is recommended.

H2O: 100 mg/mL (241.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.96 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.4125 mL	12.0627 mL	24.1255 mL	120.6273 mL
5 mM	0.4825 mL	2.4125 mL	4.8251 mL	24.1255 mL
10 mM	0.2413 mL	1.2063 mL	2.4125 mL	12.0627 mL
20 mM	0.1206 mL	0.6031 mL	1.2063 mL	6.0314 mL
50 mM	0.0483 mL	0.2413 mL	0.4825 mL	2.4125 mL
100 mM	0.0241 mL	0.1206 mL	0.2413 mL	1.2063 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc