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Azide-PEG3-Desthiobiotin (Synonyms: Azide-PEG3-Desthiobiotin)

Name: Azide-PEG3-Desthiobiotin
Brand: TargetMol
SKU: T38888
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T38888 Copy Product Info

Purity: 99.27%

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Azide-PEG3-Desthiobiotin is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Azide-PEG3-Desthiobiotin

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Catalog No. T38888

Synonyms Azide-PEG3-Desthiobiotin

Azide-PEG3-Desthiobiotin is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Cas No. 1426828-06-9

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Pack Size	Price	USA Stock	Global Stock
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$272	-	In Stock
50 mg	$438	-	In Stock
100 mg	$658	-	In Stock
500 mg	$1,380	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.27%

Appearance:Oil

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Azide-PEG3-Desthiobiotin is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
In vitro	PROTACs, comprising two distinct ligands connected by a linker—one ligand for an E3 ubiquitin ligase and the other for the target protein—exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. [1]
Synonyms	Azide-PEG3-Desthiobiotin

Chemical Properties

Molecular Weight	414.5
Formula	C₁₈H₃₄N₆O₅
Cas No.	1426828-06-9
Smiles	C(CCCCC(NCCOCCOCCOCCN=[N+]=[N-])=O)[C@@H]1[C@H](C)NC(=O)N1

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (241.25 mM), Sonication is recommended.

H2O: 100 mg/mL (241.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.4125 mL	12.0627 mL	24.1255 mL	120.6273 mL
5 mM	0.4825 mL	2.4125 mL	4.8251 mL	24.1255 mL
10 mM	0.2413 mL	1.2063 mL	2.4125 mL	12.0627 mL
20 mM	0.1206 mL	0.6031 mL	1.2063 mL	6.0314 mL
50 mM	0.0483 mL	0.2413 mL	0.4825 mL	2.4125 mL
100 mM	0.0241 mL	0.1206 mL	0.2413 mL	1.2063 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc