Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SBP-0636457 (SB1-0636457) is a SMAC mimetic and an inhibitor of inhibitor of apoptosis (IAP) proteins. It specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM. SBP-0636457 holds potential for research in the fields of solid tumors and hematologic cancers.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | Inquiry | $ 996.00 |
Description | SBP-0636457 (SB1-0636457) is a SMAC mimetic and an inhibitor of inhibitor of apoptosis (IAP) proteins. It specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM. SBP-0636457 holds potential for research in the fields of solid tumors and hematologic cancers. |
Targets&IC50 | XIAP:0.27 μM (Ki) |
In vitro | SBP-0636457, at concentrations ranging from 1-20 μM, exhibits no cytotoxic effects on BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines, ensuring its safety up to a 20μM threshold[1]. Further, when administered at doses between 10-1000 nM for 20 hours, SBP-0636457 effectively enhances TRAIL-mediated apoptosis in MDA-MB-231 cells, achieving an EC50 of 9 nM, thus confirming its potency as a TRAIL-sensitizing agent[1]. |
Synonyms | SBI-0636457, SB1-0636457, SBP-0636457 |
Molecular Weight | 456.587 |
Formula | C25H36N4O4 |
CAS No. | 1422180-49-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SBP-0636457 1422180-49-1 SBI-0636457 SBP0636457 SBP 0636457 SB1-0636457 SBI0636457 SBI 0636457 inhibitor inhibit