SBP-0636457 (SB1-0636457) is a SMAC mimetic and IAP inhibitor that specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM, holding potential for research in solid tumors and hematologic cancers.

XIAP:0.27 μM (Ki)

SBP-0636457, at concentrations ranging from 1-20 μM, exhibits no cytotoxic effects on BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines, ensuring its safety up to a 20μM threshold[1]. Further, when administered at doses between 10-1000 nM for 20 hours, SBP-0636457 effectively enhances TRAIL-mediated apoptosis in MDA-MB-231 cells, achieving an EC50 of 9 nM, thus confirming its potency as a TRAIL-sensitizing agent[1].