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SBP-0636457
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Catalog No. T38857Cas No. 1422180-49-1
Alias SBP-0636457, SBI-0636457, SB1-0636457
SBP-0636457 (SB1-0636457) is a SMAC mimetic and IAP inhibitor that specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM, holding potential for research in solid tumors and hematologic cancers.
SBP-0636457
Copy Product Info😃Good
Catalog No. T38857Alias SBP-0636457, SBI-0636457, SB1-0636457Cas No. 1422180-49-1
SBP-0636457 (SB1-0636457) is a SMAC mimetic and IAP inhibitor that specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM, holding potential for research in solid tumors and hematologic cancers.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $996 | Inquiry | Inquiry |
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Product Introduction
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Chemical Properties
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| Description | SBP-0636457 (SB1-0636457) is a SMAC mimetic and IAP inhibitor that specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM, holding potential for research in solid tumors and hematologic cancers. |
| Targets&IC50 | XIAP:0.27 μM (Ki) |
| In vitro | SBP-0636457, at concentrations ranging from 1-20 μM, exhibits no cytotoxic effects on BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines, ensuring its safety up to a 20μM threshold[1]. Further, when administered at doses between 10-1000 nM for 20 hours, SBP-0636457 effectively enhances TRAIL-mediated apoptosis in MDA-MB-231 cells, achieving an EC50 of 9 nM, thus confirming its potency as a TRAIL-sensitizing agent[1]. |
| Synonyms | SBP-0636457, SBI-0636457, SB1-0636457 |
| Molecular Weight | 456.587 |
| Formula | C25H36N4O4 |
| Cas No. | 1422180-49-1 |
| Smiles | [H][C@]12CC(C)(C)[C@H](N1C(=O)[C@H](CCO2)NC(=O)[C@H](C)NC)C(=O)N[C@@H]1CCCc2ccccc12 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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