Folate-PEG3-alkyne

Name: Folate-PEG3-alkyne
Brand: TargetMol
SKU: T38629
Rating: 4.5 (1 reviews)

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Catalog No. T38629Cas No. 1245285-73-7

Alias Folate-PEG3-alkyne

Folate-PEG3-alkyne is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Folate-PEG3-alkyne

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Catalog No. T38629Alias Folate-PEG3-alkyneCas No. 1245285-73-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Folate-PEG3-alkyne is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro	PROTACs, comprising two ligands linked together, bind to an E3 ubiquitin ligase and a target protein, respectively, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Synonyms	Folate-PEG3-alkyne

Chemical Properties

Molecular Weight	610.628
Formula	C₂₈H₃₄N₈O₈
Cas No.	1245285-73-7
Smiles	Nc1nc2[nH]cc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)NCCOCCOCCOCC#C)C(O)=O)nc2c(=O)n1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc