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MMRi64

Name: MMRi64
Brand: TargetMol
SKU: T28078
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28078Cas No. 430458-66-5

MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2 and MdmX in leukemia cells.MMRi64 MMRi64 can be used in cancer research.

MMRi64

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Purity: 99.93%

Catalog No. T28078Cas No. 430458-66-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$193	In Stock	In Stock
25 mg	$333	In Stock	In Stock
50 mg	$497	In Stock	In Stock
100 mg	$693	In Stock	In Stock
500 mg	$1,450	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

MMRi64 AI Summary

MMRi64 demonstrates significant bioactivity, notably inhibiting the growth of Plasmodium falciparum in red blood cells with EC50 values of 144.1 nM and 152.2 nM for the W2 (drug-resistant) and 3D7 (drug-susceptible) strains, respectively. It shows varying degrees of efficacy against different P. falciparum strains, including K1 (EC50 = 1673.5 nM) and 3D7 (EC50 = 1497.9 nM). Additionally, it exhibits high Inhibition Frequency Index (IFI) of 7.692%. It also displays cytotoxicity in human HepG2 cells and significant inhibition (CC50 > 48960.0 nM) in the Huh7 hepatocellular carcinoma cell line. The compound further shows inhibition of Leishmania Mexicana promastigotes with variable effects depending on transporter protein expression. Moreover, MMRi64 inhibits the p53-MDM2 interaction with an IC50 value of 4400.0 nM. These bioactivities suggest that MMRi64 has potential as an antimalarial and anti-cancer agent, and it also may affect other parasitic diseases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	410.3
Formula	C₂₂H₁₇Cl₂N₃O
Cas No.	430458-66-5
Smiles	C(NC1=CC(C)=CC=N1)(C2=C(O)C3=C(C=C2)C=CC=N3)C4=C(Cl)C(Cl)=CC=C4
Relative Density.	1.402 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (146.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4372 mL	12.1862 mL	24.3724 mL	121.8621 mL
5 mM	0.4874 mL	2.4372 mL	4.8745 mL	24.3724 mL
10 mM	0.2437 mL	1.2186 mL	2.4372 mL	12.1862 mL
20 mM	0.1219 mL	0.6093 mL	1.2186 mL	6.0931 mL
50 mM	0.0487 mL	0.2437 mL	0.4874 mL	2.4372 mL
100 mM	0.0244 mL	0.1219 mL	0.2437 mL	1.2186 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc