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AHR antagonist 5 free base

Catalog No. T39762 CAS 2247950-42-9

AhR antagonist 5 free base is an orally active antagonist of AhR with IC50s of ~35-150 nM in human and rodent cell lines.

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AHR antagonist 5 free base, CAS 2247950-42-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AHR antagonist 5 free base is an orally active antagonist of AHR with IC50s of ~35-150 nM in human and rodent cell lines.
In vitro	AHR antagonist 5 free base induces an activated human T cell state and inhibits CYP1A1 and interleukin (IL)-22 gene expression. AHR antagonist 5 increases pro-inflammatory cytokines, such as IL-2 and IL-9[1].

Molecular Weight	441.5
Formula	C25H24FN7
CAS No.	2247950-42-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (113.25 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Marta Sanchez-Martin, et al. Ahr inhibitors and uses thereof. WO2021142180A1.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

AHR antagonist 5 free base 2247950-42-9 Immunology/Inflammation Aryl Hydrocarbon Receptor Inhibitor inhibitor inhibit

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