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Pomalidomide-5-O-CH3

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Catalog No. T39032Cas No. 1547163-02-9
Alias Pomalidomide-5-O-CH3

Pomalidomide-5-O-CH3, a derivative of Pomalidomide, serves as a specific ligand for cereblon (CRBN) protein recruitment. It can be linked to the protein ligand to create a PROTAC.

Pomalidomide-5-O-CH3

Pomalidomide-5-O-CH3

😃Good
Catalog No. T39032Alias Pomalidomide-5-O-CH3Cas No. 1547163-02-9
Pomalidomide-5-O-CH3, a derivative of Pomalidomide, serves as a specific ligand for cereblon (CRBN) protein recruitment. It can be linked to the protein ligand to create a PROTAC.
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Product Introduction

Bioactivity
Description
Pomalidomide-5-O-CH3, a derivative of Pomalidomide, serves as a specific ligand for cereblon (CRBN) protein recruitment. It can be linked to the protein ligand to create a PROTAC.
In vitro
PROTACs are composed of two ligands joined by a linker: one ligand binds to an E3 ubiquitin ligase, and the other targets a specific protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins[1].
SynonymsPomalidomide-5-O-CH3
Chemical Properties
Molecular Weight303.274
FormulaC14H13N3O5
Cas No.1547163-02-9
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Pomalidomide-5-O-CH-3Pomalidomide5OCH3Pomalidomide 5 O CH3
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