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(20607)
Research Areas Research AreasCardiovascular System
Cardiovascular diseases (CVDs) encompass disorders affecting the heart and blood vessels, including coronary artery disease, heart failure, hypertensive heart disease, cardiomyopathies, arrhythmias, congenital defects, and thromboembolic conditions. CVDs are the leading cause of death globally, accounting for the majority of mortality in both men and women. Given their substantial clinical and socioeconomic burden, research in cardiovascular biology, vascular inflammation, lipid metabolism, and thrombosis is critical for advancing preventive strategies, optimizing pharmacological interventions, and reducing long-term complications.
Azelaprag
AMG 986
T143902049980-18-7In house
Azelaprag (Example 263.0) is a candidate active molecule (EC50= 0.32 nM) for an apelin receptor agonist. Azelaprag can be used to treat nervous system diseases, cardiovascular diseases.
- $107
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5-HT2 antagonist 1
T12597191592-09-3In house
5-HT2 antagonist 1 is a potent 5-HT2 receptor antagonist with weak α1 adrenoceptor blocking activity.
- $714
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Resiniferatoxin
RTX, [3H]resiniferatoxin
T3429557444-62-9
Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE.
- $456
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QTY
Tirzepatide
LY-3298176
TP11112023788-19-2
Tirzepatide (LY-3298176) is a dual agonist of glucose-dependent polypeptide (GIP) (EC50=0.042 nM) and glucagon-like peptide-1 (GLP-1) (EC50=0.086 nM) receptors, and it has neuroprotective activity. It can improve blood pressure and lower low-density lipoprotein (LDL) cholesterol and triglycerides, and can be used to study diabetes and obesity.
- $266
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AZD0780
PCSK9-IN-12, EX-A6975
T643622455427-91-3
AZD0780 (EX-A6975, PCSK9-IN-12) is an orally active PCSK9 inhibitor with high affinity for PCSK9 (Kd < 200 nM). It binds to a specific pocket in the C-terminal domain of PCSK9 without affecting the PCSK9–LDLR interaction. AZD0780 blocks the lysosomal trafficking of the PCSK9–LDLR complex and prevents PCSK9-induced LDLR degradation, making it useful for studies related to hypercholesterolemia.
- $66
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Resmetirom
Cited
VIA-3196, MGL3196
T3595920509-32-6
Resmetirom (MGL-3196) is a THR-β agonist (EC50=0.21 μM), with high selectivity and oral activity. Resmetirom can be used in the research of non-cirrhotic and non-alcoholic steatohepatitis.
- $33
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CitedRuxolitinib Cited
INCB018424, (R)-Ruxolitinib
T1829941678-49-5
Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis.
- $53
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CitedAZD5462
T638382787501-83-9
AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
- $289
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GSK484 hydrochloride Cited
GTPL8577, AOB6992
TQ00671652591-81-5
GSK484 hydrochloride (GTPL8577) is a reversible peptidyl-arginine deiminase 4 (PAD4) inhibitor. It binds to PAD4 with high affinity, with IC50 of 250 and 50 nM in the presence and absence of 2 mM calcium, respectively. GSK484 promotes the radiosensitivity of colorectal cancer (CRC) and inhibits NET formation in vitro and in vivo.
- $65
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CitedD-GsMTx4 TFA
T37697L
D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglia reactivity. toxicity and microglia reactivity.D-GsMTx4 TFA prevented myocardial infarction in a mouse model of ischemia/reperfusion and can be used to characterize the role of excitatory MSCs in normal physiology and pathology.
- $163
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CNS-5161 hydrochloride
CNS 5161A
T10852160756-38-7In house
CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
- $509
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Ceruletide Cited
FI-6934, Cerulein, Caerulein
T1493217650-98-5
Ceruletide is a decapeptide that serves as a safe and effective cholecystokinin receptor agonist, exerting a direct spasmogenic effect on the gallbladder muscle and bile ducts, and is commonly used to establish pancreatitis models.
- $31
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CitedEvolocumab
T99201256937-27-5
Evolocumab is an inhibitor of the humanized monoclonal antibody PCSK9. It binds to circulating PCSK9 protein, resulting in inhibition of PCSK9 binding to LDLR. It can be used in studies of hypercholesterolemia and atherosclerotic cardiovascular disease.
- $228
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KDM4-IN-4
T603542230475-63-3In house
KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It inhibits H3K4Me3 binding to the Tudor domain in cellular contexts with an EC50 value of 105 μM, holding potential for anticancer research applications [1].
- $293
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Candoxatril
UK 79300
T10671123122-55-4In house
Candoxatril (UK 79300) is an orally active neutral peptide endonuclease (NEP, EC 3.4.24.11) inhibitor that improves exercise capacity in patients with chronic heart failure undergoing angiotensin-converting enzyme inhibition.
- $293
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LDL-IN-3
T10063180908-67-2In house
LDL-IN-3 shows anti-atherosclerotic and antioxidant activities.
- $388
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Alirocumab
T99161245916-14-6
Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.
- $247
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Yoda 1 Cited
T7506448947-81-7
Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1 (EC50=17.1/26.6 μM). Yoda 1 is also an inhibitor of glycine transporter protein 2 (GlyT2).
- $39
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CitedGalunisertib Cited
LY2157299
T2510700874-72-2
Galunisertib (LY2157299) is a TGF-β receptor type I (TGF-βRI) inhibitor (IC50=56 nM) that is selective. Galunisertib has antitumor activity and can be used in combination with PD-1 inhibitors.
- $40
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CitedAbelacimab
MAA868, MAA 868
T768942098724-83-3
Abelacimab (MAA868), a fully human IgG1 monoclonal antibody that binds to and blocks the activation of FXI, is an anticoagulant used in the study of thromboembolic diseases.
- $228
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Ecastolol
T1114877695-52-4In house
Ecastolol has anti-angina activity and is an adrenergic receptor antagonist.
- $388
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Finerenone Cited
BAY94-8862, BAY-94-8862, BAY-948862, BAY948862, BAY 94-8862, BAY 948862
T213951050477-31-0
Finerenone (BAY-948862) is a nonsteroidal antagonist of the mineralocorticoid receptor (MR) (IC50=18 nM) with selective and oral activity. Finerenone is used in the treatment of patients with chronic kidney disease with type 2 diabetes.
- $31
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CitedMetformin Cited
1,1-Dimethylbiguanide
T8526657-24-9
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research.
- $39
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