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Hydrocinchonine (Synonyms: Dihydrocinchonine)

Name: Hydrocinchonine
Brand: TargetMol
SKU: T21156
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T21156 Copy Product Info

Purity: 99.91%

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Hydrocinchonine is reported to have multidrug resistance reversal activity, which can weaken drug resistance by inhibiting the function of P-gp and possibly affecting its expression. In MES-SA/DX5 cells, the combination of Hydrocinchonine and Paclitaxel can enhance the apoptosis.

Hydrocinchonine

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Catalog No. T21156

Synonyms Dihydrocinchonine

Cas No. 485-65-4

Pack Size	Price	USA Stock	Global Stock	Quantity
50 mg	$31	-	In Stock
100 mg	$48	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Hydrocinchonine is reported to have multidrug resistance reversal activity, which can weaken drug resistance by inhibiting the function of P-gp and possibly affecting its expression. In MES-SA/DX5 cells, the combination of Hydrocinchonine and Paclitaxel can enhance the apoptosis.
In vitro	Hydrocinchonine (10 μM, 24) can enhance the cytotoxicity induced by taxol (TAX) in MES-SA (IC50 = 18.59nm)/DX5 (IC50 = 632.64nm) cells expressing P-gp, but has no obvious toxicity to both cell lines [1]. Hydrocinchonine (10 μM, 24 hours) can effectively restore the sensitivity of drug-resistant cancer cells to tax-induced apoptosis, resulting in a large number of deaths in MES-SA/DX5 cells [1]. Hydrocinchonine (10 μM, 1 hour) can effectively inhibit the function of P-gp and prevent it from pumping the substrate out of the cell, thus making the drug accumulate in MES-SA/DX5 cells [1].
Synonyms	Dihydrocinchonine

Chemical Properties

Molecular Weight	296.41
Formula	C₁₉H₂₄N₂O
Cas No.	485-65-4
Smiles	[C@@H](O)([C@@]1([N@@]2C[C@H](CC)[C@](C1)(CC2)[H])[H])C=3C4=C(N=CC3)C=CC=C4
Relative Density.	1.18 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 4 mg/mL (13.49 mM), Sonication is recommended.

DMSO: Soluble

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.3737 mL	16.8685 mL	33.7371 mL	168.6853 mL
5 mM	0.6747 mL	3.3737 mL	6.7474 mL	33.7371 mL
10 mM	0.3374 mL	1.6869 mL	3.3737 mL	16.8685 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc