EC0489

Name: EC0489
Brand: TargetMol
SKU: T13672
Rating: 4.5 (1 reviews)

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Catalog No. T13672Cas No. 1096702-14-5

EC0489 is a small molecule-drug conjugate (SMDC) that combines folic acid and desacetyl vinblastine hydrazide, serving as a high-affinity ligand for the folate receptor (FR) in refractory or metastatic tumors.

EC0489

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Catalog No. T13672Cas No. 1096702-14-5

Pack Size	Price	Availability	Quantity
25 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	EC0489 is a small molecule-drug conjugate (SMDC) that combines folic acid and desacetyl vinblastine hydrazide, serving as a high-affinity ligand for the folate receptor (FR) in refractory or metastatic tumors.
In vitro	FR-positive KB cells are highly sensitive to EC0489 with an IC50 of 5 nM.The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50).
In vivo	EC0489, administered at doses of 2, 3, and 4 μmol/kg, exhibits dose-dependent antitumor activity in mouse KB tumor models. Furthermore, EC0489 demonstrates a favorable toxicology profile in rats.

Chemical Properties

Molecular Weight	2550.7
Formula	C₁₁₁H₁₅₆N₂₂O₄₃S₂
Cas No.	1096702-14-5
Relative Density.	1.66 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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