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Kokusaginine
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Catalog No. T124794 Copy Product Info
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Kokusaginine is a furoquinoline alkaloid that inhibits acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptosis-inducing effects in MCF-7/ADR cells and is utilized in biochemical research focused on cholinesterase inhibition, apoptosis regulation, and multidrug-resistant cancer cell signaling pathways.
Cas No. 484-08-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $695 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:White
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| Description | Kokusaginine is a furoquinoline alkaloid that inhibits acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptosis-inducing effects in MCF-7/ADR cells and is utilized in biochemical research focused on cholinesterase inhibition, apoptosis regulation, and multidrug-resistant cancer cell signaling pathways. |
| In vitro | Methods：Human parental breast cancer cells and drug-resistant cell lines were treated with kokusaginine at concentrations of 0–30 μM and 6–24 μM. Tubulin polymerization, cell proliferation and apoptosis were detected, and the IC₅₀ values for proliferation inhibition were determined. Results：Kokusaginine at 0–30 μM inhibited tubulin polymerization and thereby arrested cell proliferation. The IC₅₀ values for MCF-7, MDA-MB-231, MCF-7/ADR and MDA-MB-231/ADR were 7.23 μM, 4.62 μM, 9.01 μM and 10.19 μM, respectively [2]. Within the concentration range of 6–24 μM, kokusaginine induced apoptosis in MCF-7 and its drug-resistant strain MCF-7/ADR in a dose-dependent manner [2]. |
| Molecular Weight | 259.26 |
| Formula | C14H13NO4 |
| Cas No. | 484-08-2 |
| Smiles | N1=C2OC=CC2=C(OC)C=3C=C(OC)C(OC)=CC13 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Kokusaginine chemical structure | Kokusaginine in vitro | Kokusaginine formula | Kokusaginine molecular weight
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