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Tivumecirnon

Name: Tivumecirnon
Brand: TargetMol
SKU: T69834
Price: 169 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69834Cas No. 2174938-78-2

Alias FLX475, FLX 475

Tivumecirnon (FLX475) is a selective and orally active CCR4 antagonist that inhibits the infiltration and migration of regulatory T cells (Tregs) into the tumour microenvironment, exhibiting antitumour activity.

Tivumecirnon

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Purity: 99.88%

Catalog No. T69834Alias FLX475, FLX 475Cas No. 2174938-78-2

Pack Size	Price	Availability
1 mg	$169	In Stock
5 mg	$428	In Stock
10 mg	$695	In Stock
25 mg	$1,390	In Stock
50 mg	$2,230	In Stock
100 mg	$3,100	In Stock
1 mL x 10 mM (in DMSO)	$513	In Stock

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Batch Information

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Purity:99.88%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tivumecirnon (FLX475) is a selective and orally active CCR4 antagonist that inhibits the infiltration and migration of regulatory T cells (Tregs) into the tumour microenvironment, exhibiting antitumour activity.
Synonyms	FLX475, FLX 475

Chemical Properties

Molecular Weight	543.41
Formula	C₂₄H₂₇Cl₂F₃N₆O
Cas No.	2174938-78-2
Smiles	[C@H](C)(N1C=2C(C(C(F)(F)F)=N1)=NC=C(N2)N3CC(C3)[C@@H]4CN(CCO)CCC4)C5=C(Cl)C=C(Cl)C=C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (147.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8402 mL	9.2012 mL	18.4023 mL	92.0116 mL
5 mM	0.3680 mL	1.8402 mL	3.6805 mL	18.4023 mL
10 mM	0.1840 mL	0.9201 mL	1.8402 mL	9.2012 mL
20 mM	0.0920 mL	0.4601 mL	0.9201 mL	4.6006 mL
50 mM	0.0368 mL	0.1840 mL	0.3680 mL	1.8402 mL
100 mM	0.0184 mL	0.0920 mL	0.1840 mL	0.9201 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc