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LAS17

Name: LAS17
Brand: TargetMol
SKU: T39906
Price: 249 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39906Cas No. 2362527-67-9

LAS17 is a selective and highly effective inhibitor of glutathione S-transferase Pi (GSTP1), which inhibits GSTP1 activity in vitro in a concentration-dependent manner. LAS17 has anti-tumor activity and inhibits breast cancer cell growth.

LAS17

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Purity: 97.06%

Catalog No. T39906Cas No. 2362527-67-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$249	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.06%

Appearance:Liquid

Color:Transparent

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Product Introduction

Bioactivity

Description	LAS17 is a selective and highly effective inhibitor of glutathione S-transferase Pi (GSTP1), which inhibits GSTP1 activity in vitro in a concentration-dependent manner. LAS17 has anti-tumor activity and inhibits breast cancer cell growth.
In vitro	METHODS: To determine whether LAS17 (0-100 μM) inhibits GSTP1 activity, an in vitro activity assay was performed, monitoring the transfer of glutathione (GSH) to 1-bromo-2,4-dinitrobenzene (BDNB) spectrophotometrically. RESULTS:LAS17 inhibited GSTP1 activity in vitro in a concentration-dependent manner. [1] METHODS: 231MFP cells were treated with LAS17 (10 μM, 48 hours) and their serum-free cell viability was measured. RESULTS:LAS17 treatment reduced the level of phosphorylated S6 downstream of mTOR and S6 kinase in 231MFP breast cancer cells. [2]
In vivo	METHODS: LAS17 (20 mg/kg, intraperitoneal injection, once a day) was used to treat 231MFP tumor xenografted mice in immunodeficient mice and the tumor growth was observed. RESULTS:LAS17 significantly inhibited the growth of 231MFP breast tumor xenografts in immunodeficient mice, had no cytotoxicity, and had no effect on the body weight of mice. [2]

Chemical Properties

Molecular Weight	359.25
Formula	C₁₅H₂₀Cl₂N₄O₂
Cas No.	2362527-67-9
Smiles	N([C@@H](C(OC)=O)CC(C)C)(CCCC#C)C=1N=C(Cl)N=C(Cl)N1

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (222.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7836 mL	13.9179 mL	27.8358 mL	139.1788 mL
5 mM	0.5567 mL	2.7836 mL	5.5672 mL	27.8358 mL
10 mM	0.2784 mL	1.3918 mL	2.7836 mL	13.9179 mL
20 mM	0.1392 mL	0.6959 mL	1.3918 mL	6.9589 mL
50 mM	0.0557 mL	0.2784 mL	0.5567 mL	2.7836 mL
100 mM	0.0278 mL	0.1392 mL	0.2784 mL	1.3918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc