Shopping Cart
Remove All
Your shopping cart is currently empty
HBED
Copy Product Info
😃Good
Catalog No. T32046Cas No. 35998-29-9
Alias CHEL-II, CHELII, CHEL II
HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.
HBED
Copy Product Info😃Good
Purity: 98.58%
Catalog No. T32046Alias CHEL-II, CHELII, CHEL IICas No. 35998-29-9
HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $40 | In Stock | In Stock | |
| 25 mg | $64 | In Stock | In Stock | |
| 50 mg | $91 | In Stock | In Stock | |
| 100 mg | $132 | In Stock | In Stock | |
| 500 mg | $322 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:98.58%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
HBED AI Summary
HBED demonstrates multiple bioactivities related to iron metabolism and toxicity in animal models. When administered intraperitoneally at different dosages, it affects iron levels in various organs such as the spleen, liver, feces, and urine, with both increases and decreases observed. The LD50 value for intraperitoneal administration in an iron overload rat model is greater than or equal to 800.0 mg/kg. The compound has varying ionization constants (pKa values) and differences in partition coefficients (logP) in different solvents, indicating its interactions in various pH environments and biological systems. It is suitable for use in organic solvents such as MeOH, chloroform, and cyclohexane, which highlights its applicability in different experimental setups or biological assays. Despite its low absorption rate of 5.0% in the human GI-tract and low effective permeability across a hexadecane membrane (Log Pe value of -5.1 cm s-1), the compound has near-neutral partitioning (LogD value of -0.2). HBED exhibits strong iron chelating activity, evidenced by a high stability constant of the Fe3+-compound complex (log K value of 40.0). It serves as a transporter substrate and shows interactions with various transporters in human Caco2 cells. The compound's efflux ratios vary with and without specific inhibitors, and its permeability is influenced by P-gp and MRP2 inhibitors, showing a high transporter substrate index ratio when treated with the MRP2 inhibitor MK571..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning. |
| Synonyms | CHEL-II, CHELII, CHEL II |
| Molecular Weight | 388.41 |
| Formula | C20H24N2O6 |
| Cas No. | 35998-29-9 |
| Smiles | C(N(CCN(CC1=C(O)C=CC=C1)CC(O)=O)CC(O)=O)C2=C(O)C=CC=C2 |
| Relative Density. | 1.374g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (12.87 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy HBED | purchase HBED | HBED cost | order HBED | HBED chemical structure | HBED formula | HBED molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.