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Tegaserod

🥰Excellent
Catalog No. T60680Cas No. 145158-71-0

Tegaserod is an orally available 5-HT4R agonist and 5-HT2B receptor antagonist with inhibitory effects on various 5-hydroxytryptamine receptors. Tegaserod has antitumor activity and is used in the treatment of irritable bowel syndrome (IBS).

Tegaserod
Other Forms of Tegaserod:
Tegaserod maleateT1551189188-57-6
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Tegaserod

🥰Excellent
Purity: 99.89%
Catalog No. T60680Cas No. 145158-71-0
Tegaserod is an orally available 5-HT4R agonist and 5-HT2B receptor antagonist with inhibitory effects on various 5-hydroxytryptamine receptors. Tegaserod has antitumor activity and is used in the treatment of irritable bowel syndrome (IBS).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$31In StockIn Stock
5 mg$46In StockIn Stock
10 mg$64-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
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Product Introduction

Bioactivity
Description
Tegaserod is an orally available 5-HT4R agonist and 5-HT2B receptor antagonist with inhibitory effects on various 5-hydroxytryptamine receptors. Tegaserod has antitumor activity and is used in the treatment of irritable bowel syndrome (IBS).
In vitro
Tegaserod ( 3,5 μM; 24,48,72 h ) increased the apoptosis of A375, RPMI-7951 ( RPMI ), SH4, B16F10, MeWo and MEL-JUSO cell lines in a time- and dose-dependent manner[1].
In vivo
After subcutaneous injection of B16F10 cells in C57BL / 6J mice, tegaserod ( 5 mg / kg ; 1 times a day for 5 consecutive days ) significantly reduced tumor growth, and only a slight decrease in body weight was observed after treatment[1].
Chemical Properties
Molecular Weight301.39
FormulaC16H23N5O
Cas No.145158-71-0
SmilesN=C(NN=CC1=CNC=2C=CC(OC)=CC12)NCCCCC
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (99.54 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.59 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3180 mL16.5898 mL33.1796 mL165.8980 mL
5 mM0.6636 mL3.3180 mL6.6359 mL33.1796 mL
10 mM0.3318 mL1.6590 mL3.3180 mL16.5898 mL
20 mM0.1659 mL0.8295 mL1.6590 mL8.2949 mL
50 mM0.0664 mL0.3318 mL0.6636 mL3.3180 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

5HTReceptor5-HT45-HT2B5HT Receptor
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