Shopping Cart

Your shopping cart is currently empty

Norartocarpetin

Name: Norartocarpetin
Brand: TargetMol
SKU: T72803
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T72803 Copy Product Info

Purity: 99.97%

🥰Excellent

Norartocarpetin is a tyrosinase inhibitor with strong inhibitory activity against tyrosinase (IC₅₀ = 0.47 μM). It can be used as an anti-browning agent in food-related research and also shows significant anti-tumor activity against human lung cancer NCI-H460 cells with an IC₅₀ of 22 μM. Its anti-proliferative mechanisms mainly include regulating the Ras/Raf/MAPK signaling pathway, inducing mitochondria-dependent apoptosis, arresting the cell cycle at S phase, and inhibiting cell migration and invasion.

Norartocarpetin

Copy Product Info

🥰Excellent

Catalog No. T72803

Cas No. 520-30-9

Customer service consultation

Pack Size	Price	USA Stock	Global Stock
1 mg	$113	-	In Stock
5 mg	$289	-	In Stock
10 mg	$479	-	In Stock
25 mg	$892	-	In Stock
50 mg	$1,220	-	In Stock
1 mL x 10 mM (in DMSO)	$273	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.97%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Norartocarpetin is a tyrosinase inhibitor with strong inhibitory activity against tyrosinase (IC₅₀ = 0.47 μM). It can be used as an anti-browning agent in food-related research and also shows significant anti-tumor activity against human lung cancer NCI-H460 cells with an IC₅₀ of 22 μM. Its anti-proliferative mechanisms mainly include regulating the Ras/Raf/MAPK signaling pathway, inducing mitochondria-dependent apoptosis, arresting the cell cycle at S phase, and inhibiting cell migration and invasion.
Targets&IC50	Tyrosinase:0.47 μM, NCI-H460 cells:22 μM
In vitro	Methods: Relevant cells were treated with Norartocarpetin to detect its mushroom tyrosinase inhibitory activity; NCI-H460 and MRC-9 cells were treated with different concentrations of Norartocarpetin for 24–48 h to detect cytotoxicity, signaling pathways, apoptosis, cell cycle, invasion and migration. Results: 1 Norartocarpetin had potent mushroom tyrosinase inhibitory activity with an IC₅₀ of 0.47 μM [1]. 2 Norartocarpetin (0–100 μM, 48 h) showed dose-dependent cytotoxicity on NCI-H460 and MRC-9 cells, with IC₅₀ values of 22 μM and 85 μM, respectively. 3 Norartocarpetin (0, 11, 22, 44 μM, 24 h) could block the Ras/Raf/MAPK signaling pathway. 4 Norartocarpetin (0, 11, 22, 44 μM, 24 h) could induce apoptosis in human lung cancer NCI-H460 cells. 5 Norartocarpetin (0, 11, 22, 44 μM) could induce cell cycle arrest at the S phase. 6 Norartocarpetin (22 μM, 24 h) could inhibit cell invasion in a dose-dependent manner. 7 Norartocarpetin (0, 11, 22, 44 μM, 24 h) could significantly inhibit cell migration [2].

Chemical Properties

Molecular Weight	286.24
Formula	C₁₅H₁₀O₆
Cas No.	520-30-9
Smiles	O=C1C=C(OC=2C=C(O)C=C(O)C12)C=3C=CC(O)=CC3O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (279.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4936 mL	17.4679 mL	34.9357 mL	174.6786 mL
5 mM	0.6987 mL	3.4936 mL	6.9871 mL	34.9357 mL
10 mM	0.3494 mL	1.7468 mL	3.4936 mL	17.4679 mL
20 mM	0.1747 mL	0.8734 mL	1.7468 mL	8.7339 mL
50 mM	0.0699 mL	0.3494 mL	0.6987 mL	3.4936 mL
100 mM	0.0349 mL	0.1747 mL	0.3494 mL	1.7468 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc