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UNC8153 TFA

Catalog No. T83867 CAS 2929304-61-8

UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a 50% degradation constant (DC50) of 350 nM. At a concentration of 10 µM, UNC8153 induces NSD2 degradation and significantly diminishes histone H3 lysine 36 dimethylation (H3K36me2) levels in MM.1S multiple myeloma cells. This degradation effect can be blocked by MLN4924, an inhibitor of the ubiquitin-activating enzyme. Furthermore, UNC8153 at 20 µM inhibits the proliferation of MM.1S cells harboring an NSD2E1099K activating mutation, but not in other cell lines (MDA-MB-231, U2OS, or HEK293) expressing wild-type NSD2. Additionally, UNC8153 at the same concentration impedes the attachment and migration of MM.1S cells, indicating its potential therapeutic implications for certain cancers.

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UNC8153 TFA, CAS 2929304-61-8

Pack Size	Availability	Price/USD
1 mg	35 days	$ 178.00
5 mg	35 days	$ 690.00
10 mg	35 days	$ 1,140.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	697.70
Formula	C33H37N5O5.CF3COOH
CAS No.	2929304-61-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 30 mg/mll

Ethanol: 30 mg/ml

DMSO: 30 mg/ml

PBS pH 7.2: 5 mg/ml

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UNC8153 TFA 2929304-61-8 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.