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NEO-811
(Synonyms: NEO811, NEO 811) Copy Product Info
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Synonyms: NEO811, NEO 811
Catalog No. T217535 Copy Product Info
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NEO-811 is a potent, selective, and cereblon (CRBN)-dependent E3 ubiquitin ligase-mediated proteolytic inhibitor that targets ARNT (HIF-1β). NEO-811 blocks ccRCC signaling pathways by promoting degradation of ARNT, thereby inhibiting tumor cell survival and proliferation. NEO-811 is used in targeted protein degradation research systems to study CRBN-dependent ubiquitination, hypoxia-inducible factor signaling regulation, and clear cell renal cell carcinoma (ccRCC) molecular pathway modulation in cellular oncology models.
NEO-811
Cas No. 3084635-77-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $393 | 10-14 weeks | 10-14 weeks | |
| 5 mg | $883 | 10-14 weeks | 10-14 weeks | |
| 25 mg | $1,980 | 10-14 weeks | 10-14 weeks | |
| 100 mg | $4,570 | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NEO-811 is a potent, selective, and cereblon (CRBN)-dependent E3 ubiquitin ligase-mediated proteolytic inhibitor that targets ARNT (HIF-1β). NEO-811 blocks ccRCC signaling pathways by promoting degradation of ARNT, thereby inhibiting tumor cell survival and proliferation. NEO-811 is used in targeted protein degradation research systems to study CRBN-dependent ubiquitination, hypoxia-inducible factor signaling regulation, and clear cell renal cell carcinoma (ccRCC) molecular pathway modulation in cellular oncology models. |
| In vivo | Method: In vivo administration of NEO-811 in clear cell renal cell carcinoma (ccRCC) xenograft and patient-derived xenograft (PDX) mouse models. Result: NEO-811 induced regression of ccRCC tumors as a single agent and remained effective in HIF-2α G323E mutant models resistant to HIF-2α antagonists. In PDX models, antitumor activity was superior to clinically available HIF-2 antagonists and VEGFR tyrosine kinase inhibitors.[1] |
| Synonyms | NEO811, NEO 811 |
| Molecular Weight | 543.59 |
| Formula | C30H30FN5O4 |
| Cas No. | 3084635-77-5 |
| Smiles | O[C@]1(C(C)(C)CN(CC2=CC=C(C=C2)C=3N=CON3)CC1)C4=C(F)C5=C(C=C4)N=CC(=C5)C6C(=O)NC(=O)CC6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: NEO-811 in vivo | NEO-811 formula | NEO-811 molecular weight
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