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BAY-0069

Name: BAY-0069
Brand: TargetMol
SKU: T67936
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67936Cas No. 420826-65-9

BAY-0069 is a potent and selective PPARγ transactivator, inhibiting human PPARγ and murine PPARγ with IC50 values of 6.3 nM and 24 nM, respectively. BAY-0069 can be used in cancer research.

BAY-0069

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Purity: 99.42%

Catalog No. T67936Cas No. 420826-65-9

BAY-0069 is a potent and selective PPARγ transactivator, inhibiting human PPARγ and murine PPARγ with IC50 values of 6.3 nM and 24 nM, respectively. BAY-0069 can be used in cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	In Stock	In Stock
10 mg	$54	In Stock	In Stock
25 mg	$121	In Stock	In Stock
50 mg	$191	In Stock	In Stock
100 mg	$289	In Stock	In Stock
200 mg	$411	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.42%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BAY-0069 is a potent and selective PPARγ transactivator, inhibiting human PPARγ and murine PPARγ with IC50 values of 6.3 nM and 24 nM, respectively. BAY-0069 can be used in cancer research.
Targets&IC50	CYP2C8:4.3 μM, PPARγ (rat):24 nM, PPARγ (human):6.3 nM
In vitro	BAY-0069 (0.0001, 0.001, 0.01, 0.01 and 1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9.[1]
In vivo	BAY-0069 (1 μM; 1 h) exhibits superior microsomal stability, with a CL(b,hmic) of 0.47 L/h/kg in human liver microsomes and a CL(b,rhep) of 3.9 L/h/kg in rat liver hepatocytes.[1]

Chemical Properties

Molecular Weight	466.28
Formula	C₂₂H₁₆BrN₃O₄
Cas No.	420826-65-9
Smiles	N(C(=O)C1=CC(N(=O)=O)=CC=C1Br)C=2C=C3C(OC(=N3)C4=CC=C(CC)C=C4)=CC2
Relative Density.	1.530 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (193.02 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1446 mL	10.7232 mL	21.4463 mL	107.2317 mL
5 mM	0.4289 mL	2.1446 mL	4.2893 mL	21.4463 mL
10 mM	0.2145 mL	1.0723 mL	2.1446 mL	10.7232 mL
20 mM	0.1072 mL	0.5362 mL	1.0723 mL	5.3616 mL
50 mM	0.0429 mL	0.2145 mL	0.4289 mL	2.1446 mL
100 mM	0.0214 mL	0.1072 mL	0.2145 mL	1.0723 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc