Cytochalasin E

Name: Cytochalasin E
Brand: TargetMol
SKU: T15039
Rating: 4.5 (1 reviews)

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Catalog No. T15039Cas No. 36011-19-5

Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elongation.

Cytochalasin E

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Catalog No. T15039Cas No. 36011-19-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$168	35 days	35 days
5 mg	$665	35 days	35 days
10 mg	$1,240	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elongation.
In vitro	Cytochalasin E significantly inhibits A549 cell growth in a dose-dependent manner and induces upregulation of autophagy-related protein (LC3-II) and SQSTM1/p62 [3].

Chemical Properties

Molecular Weight	495.56
Formula	C₂₈H₃₃NO₇
Cas No.	36011-19-5
Smiles	C[C@H]1[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]22OC(=O)O\C=C\[C@@](C)(O)C(=O)[C@@H](C)C\C=C\[C@H]2[C@@H]2O[C@]12C
Relative Density.	1.3g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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