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Propargyl-C8-amido-PEG2-NHS ester

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Catalog No. T38401Cas No. 1006592-59-1
Alias Propargyl-C8-amido-PEG2-NHS ester

Propargyl-C8-amido-PEG2-NHS ester is a non-cleavable linker comprising two PEG units, primarily employed for the synthesis of antibody-drug conjugates (ADCs). This compound is essential for conjugating antibodies to drugs, enabling the targeted delivery of therapeutic agents.

Propargyl-C8-amido-PEG2-NHS ester

Propargyl-C8-amido-PEG2-NHS ester

😃Good
Catalog No. T38401Alias Propargyl-C8-amido-PEG2-NHS esterCas No. 1006592-59-1
Propargyl-C8-amido-PEG2-NHS ester is a non-cleavable linker comprising two PEG units, primarily employed for the synthesis of antibody-drug conjugates (ADCs). This compound is essential for conjugating antibodies to drugs, enabling the targeted delivery of therapeutic agents.
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Product Introduction

Bioactivity
Description
Propargyl-C8-amido-PEG2-NHS ester is a non-cleavable linker comprising two PEG units, primarily employed for the synthesis of antibody-drug conjugates (ADCs). This compound is essential for conjugating antibodies to drugs, enabling the targeted delivery of therapeutic agents.
In vitro
ADCs consist of an antibody linked to an ADC cytotoxin via an ADC linker[1].
SynonymsPropargyl-C8-amido-PEG2-NHS ester
Chemical Properties
Molecular Weight438.51
FormulaC22H34N2O7
Cas No.1006592-59-1
SmilesO=C(CCCCCCCCC#C)NCCOCCOCCC(=O)ON1C(=O)CCC1=O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Keywords

Propargyl-C-8-amido-PEG2-NHS esterPropargylC8amidoPEG2NHS esterPropargyl C8 amido PEG2 NHS esterADCLinkerADC Linker
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