Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 123.00 | |
5 mg | In stock | $ 262.00 | |
10 mg | In stock | $ 455.00 | |
25 mg | In stock | $ 735.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,380.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 443.00 |
Description | AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively. |
In vitro | In NIH3T3 cells, AZD3147 (1.5-50 nM) alleviates FGF-mediated cilia extension[2]. AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly(IC50 = 0.88 nM) and IMR-32 (IC50 = 662.4 nM)[3]. |
In vivo | AZD3147 shows a CL of 78 mL/min/kg, a Vss of 2.3 L/kg, a t1/2 of 0.9 h and an F of 61% in mice[1]. |
Molecular Weight | 517.66 |
Formula | C24H31N5O4S2 |
CAS No. | 1101810-02-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 1 mg/mL
Hydrochloride acid: 100 nM
DMSO: 46.8 mg/mL (90.5 mM)
You can also refer to dose conversion for different animals. More
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AZD 3147 1101810-02-9 PI3K/Akt/mTOR signaling mTOR AZD3147 AZD-3147 inhibitor inhibit