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AZD 3147

Name: AZD 3147
Brand: TargetMol
SKU: T36200
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36200Cas No. 1101810-02-9

AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.

AZD 3147

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Purity: 99.99%

Catalog No. T36200Cas No. 1101810-02-9

AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
5 mg	$222	In Stock	In Stock
10 mg	$355	In Stock	In Stock
25 mg	$612	In Stock	In Stock
50 mg	$818	In Stock	In Stock
100 mg	$1,130	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$287	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.
In vitro	In NIH3T3 cells, AZD3147 (1.5-50 nM) alleviates FGF-mediated cilia extension[2]. AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly(IC50 = 0.88 nM) and IMR-32 (IC50 = 662.4 nM)[3].
In vivo	AZD3147 shows a CL of 78 mL/min/kg, a Vss of 2.3 L/kg, a t1/2 of 0.9 h and an F of 61% in mice[1].

Chemical Properties

Molecular Weight	517.66
Formula	C₂₄H₃₁N₅O₄S₂
Cas No.	1101810-02-9
Smiles	S(=O)(=O)(C1(CC1)C=2C=C(N=C(N2)C3=CC=C(NC(NCCO)=S)C=C3)N4[C@@H](C)COCC4)C5CC5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 1 mg/mL (1.93 mM), Sonication is recommended.

Hydrochloride acid: 100 mg/mL (193.18 mM), Sonication is recommended.

DMSO: 46.8 mg/mL (90.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Hydrochloride acid

	1mg	5mg	10mg	50mg
5 mM	0.3864 mL	1.9318 mL	3.8635 mL	19.3177 mL
10 mM	0.1932 mL	0.9659 mL	1.9318 mL	9.6588 mL
20 mM	0.0966 mL	0.4829 mL	0.9659 mL	4.8294 mL
50 mM	0.0386 mL	0.1932 mL	0.3864 mL	1.9318 mL

Hydrochloride acid

	1mg	5mg	10mg	50mg
100 mM	0.0193 mL	0.0966 mL	0.1932 mL	0.9659 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc