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BGT226

Name: BGT226
Brand: TargetMol
SKU: T6072L
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6072LCas No. 915020-55-2

Alias NVP-BGT226, BGT226 free base

BGT226 (NVP-BGT226) is a novel dual PI3K/mTOR inhibitor, targeting PI3K α, β, and γ with IC50 values of 4 nM, 63 nM, and 38 nM, respectively.

BGT226

🥰Excellent

Purity: 99.51%

Catalog No. T6072LAlias NVP-BGT226, BGT226 free baseCas No. 915020-55-2

BGT226 (NVP-BGT226) is a novel dual PI3K/mTOR inhibitor, targeting PI3K α, β, and γ with IC50 values of 4 nM, 63 nM, and 38 nM, respectively.

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$98	In Stock
10 mg	$168	In Stock
25 mg	$347	In Stock
50 mg	$565	In Stock
100 mg	$859	In Stock
200 mg	$1,160	In Stock
1 mL x 10 mM (in DMSO)	$119	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.51%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BGT226 (NVP-BGT226) is a novel dual PI3K/mTOR inhibitor, targeting PI3K α, β, and γ with IC50 values of 4 nM, 63 nM, and 38 nM, respectively.
Targets&IC50	PI3Kγ:38 nM, PI3Kα:4 nM, PI3Kβ:63 nM
In vitro	Growth inhibition experiment showed that BGT226 had antitumor activity. BGT226 significantly inhibited cell growth with IC50 < 20 nM. BGT226 also induced cancer cell apoptosis at nanomolar concentration, IC50 ≤ 25 nM[1][2][3].
In vivo	BGT226 significantly delayed tumor growth on the transplanted tumor animal model. This effect was dose-dependent, accompanied by inhibition of p-p70 S6 kinase cytoplasmic expression and autophagy body formation[2].
Synonyms	NVP-BGT226, BGT226 free base

Chemical Properties

Molecular Weight	534.53
Formula	C₂₈H₂₅F₃N₆O₂
Cas No.	915020-55-2
Smiles	COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(-c4ccc(N5CCNCC5)c(c4)C(F)(F)F)c3c2c1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (121.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8708 mL	9.3540 mL	18.7080 mL	93.5401 mL
5 mM	0.3742 mL	1.8708 mL	3.7416 mL	18.7080 mL
10 mM	0.1871 mL	0.9354 mL	1.8708 mL	9.3540 mL
20 mM	0.0935 mL	0.4677 mL	0.9354 mL	4.6770 mL
50 mM	0.0374 mL	0.1871 mL	0.3742 mL	1.8708 mL
100 mM	0.0187 mL	0.0935 mL	0.1871 mL	0.9354 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc