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USP7-797

Name: USP7-797
Brand: TargetMol
SKU: T73234
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T73234Cas No. 2413944-70-2

Alias USP7-IN-7, USP7797, USP 7-797

USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency (IC50=0.44 nmol), it is effective on both wild-type and mutant p53 tumor cells, and can significantly inhibit the growth of tumor cells and induce apoptosis.

USP7-797

🥰Excellent

Purity: 95.90%

Catalog No. T73234Alias USP7-IN-7, USP7797, USP 7-797Cas No. 2413944-70-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$385	In Stock	In Stock
5 mg	$888	In Stock	In Stock
10 mg	$1,420	-	In Stock
25 mg	$2,420	-	In Stock
1 mL x 10 mM (in DMSO)	$996	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:95.90%

ee:100%

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency (IC50=0.44 nmol), it is effective on both wild-type and mutant p53 tumor cells, and can significantly inhibit the growth of tumor cells and induce apoptosis.
In vitro	Methods: USP7-797 (0-1 μM) was used to treat p53 wild-type hematological cancer cell lines, and cell viability was determined. Results: USP7-797 was cytotoxic to p53 wild-type hematological cancer cell lines, with CC50 values of 0.2, 0.2, 0.4, and 0.1 μM for M07e, OCI-AML5, MOLM13, and MM.IS, respectively. Methods: USP7-797 (0-25 μM) was used to treat p53 mutant cancer cell lines, and cell viability was determined. Results: USP7-797 was cytotoxic to p53 mutant cancer cell lines, with CC50 values of 0.5, 0.2, and 0.2 μM for H526, LA-N-2, and SK-N-DZ, respectively. Methods: USP7-797 (0-2 μM) was used to treat p53 wild-type neuroblastoma cell lines and cell viability was measured. Results: USP7-797 was cytotoxic to p53 wild-type neuroblastoma cell lines, with CC50 values of 1.9, 0.6, and 0.5 μM for SH-SY5Y, CHP-134, and NB-1, respectively. [1]
Synonyms	USP7-IN-7, USP7797, USP 7-797

Chemical Properties

Molecular Weight	510.05
Formula	C₂₇H₂₈ClN₃O₃S
Cas No.	2413944-70-2
Smiles	CC1(C)C2C1C(=O)N(CC=3SC=4C(C3)=NC=CC4C5=C(C[C@@H]6CNCCO6)C(C)=CC(Cl)=C5)C2=O

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (117.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.47 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9606 mL	9.8030 mL	19.6059 mL	98.0296 mL
5 mM	0.3921 mL	1.9606 mL	3.9212 mL	19.6059 mL
10 mM	0.1961 mL	0.9803 mL	1.9606 mL	9.8030 mL
20 mM	0.0980 mL	0.4901 mL	0.9803 mL	4.9015 mL
50 mM	0.0392 mL	0.1961 mL	0.3921 mL	1.9606 mL
100 mM	0.0196 mL	0.0980 mL	0.1961 mL	0.9803 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

USP7-797

USP7-797

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