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FT709

🥰Excellent
Catalog No. T63375Cas No. 2413991-74-7
Alias FT 709

FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.

FT709
Other Forms of FT709:
(R)-FT709T835352413991-75-8
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FT709

🥰Excellent
Catalog No. T63375Alias FT 709Cas No. 2413991-74-7
FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$287In StockIn Stock
5 mg$928In StockIn Stock
10 mg$1,480-In Stock
25 mg$2,970-In Stock
1 mL x 10 mM (in DMSO)$987-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.
Targets&IC50
USP9X:82 nM
In vitro
In HCT116 cells, treatment with 10 µM FT709 for 24 hours downregulated the expression levels of ZNF598 (a ubiquitin E3 ligase) and centrosomal protein CEP55 [1].
SynonymsFT 709
Chemical Properties
Molecular Weight498.51
FormulaC23H22N4O7S
Cas No.2413991-74-7
SmilesS(=O)(=O)(N1CC2=C(C1)CN(C([C@@H](O)C3=C4C(OC(C)=N4)=CC=C3)=O)C2)C=5C=C6C(=NC5)OCCO6
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (160.48 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.62 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0060 mL10.0299 mL20.0598 mL100.2989 mL
5 mM0.4012 mL2.0060 mL4.0120 mL20.0598 mL
10 mM0.2006 mL1.0030 mL2.0060 mL10.0299 mL
20 mM0.1003 mL0.5015 mL1.0030 mL5.0149 mL
50 mM0.0401 mL0.2006 mL0.4012 mL2.0060 mL
100 mM0.0201 mL0.1003 mL0.2006 mL1.0030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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