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MI-389

Name: MI-389
Brand: TargetMol
SKU: T33380
Price: 87 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T33380Cas No. 2222635-92-7

Alias MI389

MI-389 is a PROTAC degrader that induces the degradation of receptor tyrosine kinases (RTKs), useful in leukemia research.

MI-389

🥰Excellent

Purity: 98.12%

Catalog No. T33380Alias MI389Cas No. 2222635-92-7

MI-389 is a PROTAC degrader that induces the degradation of receptor tyrosine kinases (RTKs), useful in leukemia research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$87	-	In Stock
5 mg	$209	-	In Stock
10 mg	$312	-	In Stock
25 mg	$488	-	In Stock
50 mg	$846	-	In Stock
100 mg	$1,460	-	In Stock
1 mL x 10 mM (in DMSO)	$283	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.12%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MI-389 is a PROTAC degrader that induces the degradation of receptor tyrosine kinases (RTKs), useful in leukemia research.
Synonyms	MI389

Chemical Properties

Molecular Weight	654.69
Formula	C₃₅H₃₅FN₆O₆
Cas No.	2222635-92-7
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCCCNC(=O)C=4C(C)=C(/C=C\5/C=6C(NC5=O)=CC=C(F)C6)NC4C
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (76.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5274 mL	7.6372 mL	15.2744 mL	76.3720 mL
5 mM	0.3055 mL	1.5274 mL	3.0549 mL	15.2744 mL
10 mM	0.1527 mL	0.7637 mL	1.5274 mL	7.6372 mL
20 mM	0.0764 mL	0.3819 mL	0.7637 mL	3.8186 mL
50 mM	0.0305 mL	0.1527 mL	0.3055 mL	1.5274 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc