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Autophagyp62
p62 (SQSTM1) is a multifunctional protein involved in numerous cellular processes, including autophagy, signal transduction, and protein degradation. Within cells, p62 forms multimeric complexes, interacting with diverse proteins through its multiple functional domains. p62 plays a crucial role in autophagy by recognising and binding ubiquitinated protein aggregates, targeting them for degradation within autophagosomes. Furthermore, p62 participates in regulating the Nrf2 signalling pathway by interacting with Keap1 to activate Nrf2's transcriptional activity, thereby modulating the expression of antioxidant genes. Abnormal accumulation of p62 is associated with various diseases, including neurodegenerative disorders and cancer.
RSL3
Cited
RSL3 1S, 1S,3R-RSL3
T36461219810-16-8
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS.
- $33
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CitedIsoschaftoside
T389752012-29-0
Isoschaftoside is used as an intercrop due to its allelopathic inhibition of parasitism by Striga hermonthica, an obligate parasitic weed that can devastate the maize crop. Isoschaftoside has anti-tumor, antioxidant, and antimicrobial activities, it also possesses strong nematicidal activity against M. incognita.
- $50
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ICSN3250 HCl（1561902-73-5 Free base), ICSN 3250 HCl
T70442L1561902-79-1
ICSN3250 HCl is an mTOR inhibitor that specifically targets cancer cells, competing with and displacing phosphatidic acid in the FRB structural domain of mTOR, thereby preventing mTOR activation and leading to cytotoxicity.
- $195
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P62-mediated mitophagy inducer
PMI
T138091809031-84-2
P62-mediated mitophagy inducer (PMI) is a regulator of mitophagy.
- $30
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Z-FY-CHO
Z-Phe-Tyr-CHO
T41236167498-29-5In house
Z-FY-CHO (Z-Phe-Tyr-CHO) is a selective histone L (Cat L) inhibitor that promotes autophagy, reduces the accumulation of P62, and blocks the activation of caspase-3 and PARP.
- $37
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ARP 101
ARP101
T22034849773-63-3
ARP 101 is an effective selective matrix metalloproteinase-2 (MMP-2) inhibitor with anti-cancer activity. It induces the inhibition of HCMV through non-classical chelate 1 (SQSTM1)/p62-Keap1-Nrf2 pathways and phosphorylation of the C-terminal domain of p62, regulating autophagy and inhibiting melanogenesis.
- $100
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Bifendate
Bifendatatum
T327373536-69-3
Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.
- $32
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K67
K-67, K 67
T277092046250-48-8
K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.
- $149
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L-Selenocystine
L-Selenocystine
T3460329621-88-3
L-Selenocystine (L-Selenocystine) can be used as a building block in biologically active selenol compounds.
- $30
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2'-Aminoacetophenone
Fr14273551-93-9
Compound Fr14273 is a natural product for research related to life sciences. The catalog number is Fr14273 and the CAS number is 551-93-9.
- $29
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YTK-105
YTK105, YTK 105
T87944774192-20-0
YTK-105 is a ligand targeting autophagy that binds to p62.
- $30
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DC-LC3in-D5
T618712868312-73-4
DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B (IC₅₀ = 200 nM), resulting in impaired LC3B lipidation, accumulation of the autophagy substrate p62, and a significant reduction in the formation of autophagosome vesicles.
- $100
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Dusquetide TFA
T76040
Dusquetide (SGX942) TFA, a first-in-class innate defense regulator (IDR), modulates the innate immune response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) by interacting with p62. This compound is effective in both diminishing inflammation and enhancing the elimination of bacterial infections [1].
- Inquiry Price
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TRAF6 peptide TFA
T78221
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates promising research applications in various neurological disorders, including Alzheimer's disease (AD), Parkinson's, ALS, head trauma, epilepsy, and stroke [1].
- $95
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Atiprimod (free base)
T71176123018-47-3
Atiprimod is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis.
- $2,120
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XIE62-1004
T839452421146-32-7
XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62. This interaction promotes p62 self-aggregation and its subsequent interaction with LC3 on autophagosome membranes, thereby facilitating the delivery of cargo proteins to the autophagosome for degradation. XIE62-1004 is effective both in vitro and in vivo, displaying specificity for the wild type of p62 and exhibiting its actions in a concentration- and time-dependent manner. Additionally, it induces the degradation of mutant huntingtin in vitro and can be employed in AUTAC protein degradation systems to trigger autophagy via p62 self-aggregation and LC3 interaction.
- $620
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Antitumor agent-133
T209021
Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 μM) and Huh7 (IC50 = 8.27 μM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.
- Inquiry Price
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Fumagilin-105
T887252410081-58-0
Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.
- $3,320
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TRAF6 peptide
T76372852805-92-6
TRAF6 peptide, a specific TRAF6-p62 inhibitor, effectively inhibits NGF-dependent TrkA ubiquitination, showcasing strong research potential for neurological conditions including Alzheimer's disease (AD), Parkinson's, ALS, head trauma, epilepsy, and stroke [1].
- Inquiry Price
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Antitumor agent-81
T725602765180-17-2
Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Additionally, it exhibits dose-dependent inhibition of xenograft tumor growth in mice.
- $1,520
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