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Autophagyp62
p62 (SQSTM1) is a multifunctional protein involved in numerous cellular processes, including autophagy, signal transduction, and protein degradation. Within cells, p62 forms multimeric complexes, interacting with diverse proteins through its multiple functional domains. p62 plays a crucial role in autophagy by recognising and binding ubiquitinated protein aggregates, targeting them for degradation within autophagosomes. Furthermore, p62 participates in regulating the Nrf2 signalling pathway by interacting with Keap1 to activate Nrf2's transcriptional activity, thereby modulating the expression of antioxidant genes. Abnormal accumulation of p62 is associated with various diseases, including neurodegenerative disorders and cancer.
RSL3
T36461219810-16-8
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS.
- $33
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P62-mediated mitophagy inducer
T138091809031-84-2
P62-mediated mitophagy inducer (PMI) is a regulator of mitophagy.
- $30
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Z-FY-CHO
T41236167498-29-5In house
Z-FY-CHO (Z-Phe-Tyr-CHO) is a selective histone L (Cat L) inhibitor that promotes autophagy, reduces the accumulation of P62, and blocks the activation of caspase-3 and PARP.
- $37
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ARP 101
T22034849773-63-3
ARP 101 is an effective selective matrix metalloproteinase-2 (MMP-2) inhibitor with anti-cancer activity. It induces the inhibition of HCMV through non-classical chelate 1 (SQSTM1)/p62-Keap1-Nrf2 pathways and phosphorylation of the C-terminal domain of p62, regulating autophagy and inhibiting melanogenesis.
- $100
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XRK3F2
T133602375193-43-2
XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
- $34
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CA-5f
T51811370032-19-1
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor that works by inhibiting autophagosome-lysosome fusion.
- $40
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Bifendate
T327373536-69-3
Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.
- $32
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K67
T277092046250-48-8
K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.
- $141
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2'-Aminoacetophenone
Fr14273551-93-9
Compound Fr14273 is a natural product for research related to life sciences. The catalog number is Fr14273 and the CAS number is 551-93-9.
- $29
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YTK-105
T87944774192-20-0
YTK-105 is a ligand targeting autophagy that binds to p62.
- $30
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DC-LC3in-D5
T618712868312-73-4
DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B (IC₅₀ = 200 nM), resulting in impaired LC3B lipidation, accumulation of the autophagy substrate p62, and a significant reduction in the formation of autophagosome vesicles.
- $100
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TRAF6 peptide TFA
T78221
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates promising research applications in various neurological disorders, including Alzheimer's disease (AD), Parkinson's, ALS, head trauma, epilepsy, and stroke [1].
- $95
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Dusquetide TFA
T76040
Dusquetide (SGX942) TFA, a first-in-class innate defense regulator (IDR), modulates the innate immune response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) by interacting with p62. This compound is effective in both diminishing inflammation and enhancing the elimination of bacterial infections [1].
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XIE62-1004
T839452421146-32-7
XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62. This interaction promotes p62 self-aggregation and its subsequent interaction with LC3 on autophagosome membranes, thereby facilitating the delivery of cargo proteins to the autophagosome for degradation. XIE62-1004 is effective both in vitro and in vivo, displaying specificity for the wild type of p62 and exhibiting its actions in a concentration- and time-dependent manner. Additionally, it induces the degradation of mutant huntingtin in vitro and can be employed in AUTAC protein degradation systems to trigger autophagy via p62 self-aggregation and LC3 interaction.
- $620
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YOK-1304
T885692409960-03-6
YOK-1304, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62.
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TRAF6 peptide
T76372852805-92-6
TRAF6 peptide, a specific TRAF6-p62 inhibitor, effectively inhibits NGF-dependent TrkA ubiquitination, showcasing strong research potential for neurological conditions including Alzheimer's disease (AD), Parkinson's, ALS, head trauma, epilepsy, and stroke [1].
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Antitumor agent-81
T725602765180-17-2
Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Additionally, it exhibits dose-dependent inhibition of xenograft tumor growth in mice.
- $1,520
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Fumagilin-105
T887252410081-58-0
Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.
- $3,320
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YT-8-8
T88781892572-23-5
YT-8-8 is a ligand for the p62-ZZ domain and can activate p62-dependent selective autophagy. This compound is also applicable in AUTOTAC design.
- $1,620
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Dusquetide
T13667L931395-42-5
Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.
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YOK-2204
T885012409959-99-3
YOK-2204 is a ligand for the p62-ZZ domain and activates p62-dependent selective autophagy. It is also applicable in the design of AUTOTACs.
- $1,520
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PBA-1105b
T887622941386-60-1
PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.
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LC3in-C42
T89284
LC3in-C42 is a covalent inhibitor of LC3A B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.
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Microcolin H
TN77312408008-21-7
Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].
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