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PGP-4008

🥰Excellent
Catalog No. T28396Cas No. 365565-02-2
Alias PGP4008, PGP 4008

PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.

PGP-4008

PGP-4008

🥰Excellent
Purity: 97.99%
Catalog No. T28396Alias PGP4008, PGP 4008Cas No. 365565-02-2
PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$39In StockIn Stock
5 mg$68In StockIn Stock
10 mg$111In StockIn Stock
25 mg$209In StockIn Stock
50 mg$331In StockIn Stock
100 mg$496In StockIn Stock
200 mg$671-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:97.99%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
SynonymsPGP4008, PGP 4008
Chemical Properties
Molecular Weight393.48
FormulaC26H23N3O
Cas No.365565-02-2
SmilesO=C(Cc1ccccc1)Nc1c2CCN(Cc3ccccc3)c2nc2ccccc12
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (127.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5414 mL12.7071 mL25.4143 mL127.0713 mL
5 mM0.5083 mL2.5414 mL5.0829 mL25.4143 mL
10 mM0.2541 mL1.2707 mL2.5414 mL12.7071 mL
20 mM0.1271 mL0.6354 mL1.2707 mL6.3536 mL
50 mM0.0508 mL0.2541 mL0.5083 mL2.5414 mL
100 mM0.0254 mL0.1271 mL0.2541 mL1.2707 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PGP-4008PgpP-glycoprotein
Related Tags: buy PGP-4008 | purchase PGP-4008 | PGP-4008 cost | order PGP-4008 | PGP-4008 chemical structure | PGP-4008 formula | PGP-4008 molecular weight
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