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PGP-4008

Name: PGP-4008
Brand: TargetMol
SKU: T28396
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28396Cas No. 365565-02-2

Alias PGP4008, PGP 4008

PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.

PGP-4008

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Purity: 97.99%

Catalog No. T28396Alias PGP4008, PGP 4008Cas No. 365565-02-2

PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$39	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$111	In Stock	In Stock
25 mg	$209	In Stock	In Stock
50 mg	$331	In Stock	In Stock
100 mg	$496	In Stock	In Stock
200 mg	$671	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.99%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

PGP-4008 AI Summary

PGP-4008 exhibits significant bioactivities, including inhibitory action when combined with various chemotherapeutic agents across different cell lines, with varying IC50 values. It antagonizes P-glycoprotein and multi-drug resistance-related protein, demonstrating potential to reverse drug resistance in cancer cells. In vivo studies show that compound 44350 inhibits tumor growth in mice when administered subcutaneously, as evidenced by changes in tumor volume at different time points. Pharmacokinetic analysis reveals that the compound has a short half-life, high plasma clearance rate, high maximum plasma concentration, and a moderate-to-low volume of distribution after intraperitoneal administration in mice..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
Synonyms	PGP4008, PGP 4008

Chemical Properties

Molecular Weight	393.48
Formula	C₂₆H₂₃N₃O
Cas No.	365565-02-2
Smiles	O=C(Cc1ccccc1)Nc1c2CCN(Cc3ccccc3)c2nc2ccccc12
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (127.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5414 mL	12.7071 mL	25.4143 mL	127.0713 mL
5 mM	0.5083 mL	2.5414 mL	5.0829 mL	25.4143 mL
10 mM	0.2541 mL	1.2707 mL	2.5414 mL	12.7071 mL
20 mM	0.1271 mL	0.6354 mL	1.2707 mL	6.3536 mL
50 mM	0.0508 mL	0.2541 mL	0.5083 mL	2.5414 mL
100 mM	0.0254 mL	0.1271 mL	0.2541 mL	1.2707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc