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Alvespimycin

Name: Alvespimycin
Brand: TargetMol
SKU: T20890
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20890Cas No. 467214-20-6

Alias KOS-1022, KOS1022, KOS 1022, 17-DMAG

Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor that binds to Hsp90, exhibiting potential anticancer activity.

Alvespimycin

🥰Excellent

Purity: 99.88%

Catalog No. T20890Alias KOS-1022, KOS1022, KOS 1022, 17-DMAGCas No. 467214-20-6

Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor that binds to Hsp90, exhibiting potential anticancer activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	-	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$143	-	In Stock
25 mg	$289	-	In Stock
50 mg	$413	-	In Stock
1 mL x 10 mM (in DMSO)	$122	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.88%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor that binds to Hsp90, exhibiting potential anticancer activity.
Targets&IC50	HSP90:62 nM (EC50), GRP94:65 nM (EC50)
In vitro	After treatment with vehicle control or 1 μM Alvespimycin (17-DMAG) for 24 hours, CLL patient cells showed that Alvespimycin downregulated NF-κB signaling through IKKα and IKKβ[2].
In vivo	Treatment with vehicle (DMSO) or Alvespimycin(17-DMAG)(10 mg/kg) significantly prolonged the survival time of TCL1-SCID model mice[2].
Synonyms	KOS-1022, KOS1022, KOS 1022, 17-DMAG

Chemical Properties

Molecular Weight	616.75
Formula	C₃₂H₄₈N₄O₈
Cas No.	467214-20-6
Smiles	CO[C@H]1C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
Relative Density.	1.2

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (129.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6214 mL	8.1070 mL	16.2140 mL	81.0701 mL
5 mM	0.3243 mL	1.6214 mL	3.2428 mL	16.2140 mL
10 mM	0.1621 mL	0.8107 mL	1.6214 mL	8.1070 mL
20 mM	0.0811 mL	0.4054 mL	0.8107 mL	4.0535 mL
50 mM	0.0324 mL	0.1621 mL	0.3243 mL	1.6214 mL
100 mM	0.0162 mL	0.0811 mL	0.1621 mL	0.8107 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc