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(S,R,S)-AHPC-C6-NH2 dihydrochloride

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Catalog No. T39872Cas No. 2341796-77-6
Alias VH032-C6-NH2 dihydrochloride, (S,R,S)-AHPC-C6-NH2 dihydrochloride

(S, R, S)-AHPC-C6-NH2 dihydrochloride (also known as VH032-C6-NH2 dihydrochloride) is a synthesized compound that functions as a ligand-linker conjugate for E3 ligase. It incorporates the VH032-based VHL ligand along with a linker, which is used for the degradation of AKT PROTAC.

(S,R,S)-AHPC-C6-NH2 dihydrochloride
Other Forms of (S,R,S)-AHPC-C6-NH2 dihydrochloride:

(S,R,S)-AHPC-C6-NH2 dihydrochloride

😃Good
Catalog No. T39872Alias VH032-C6-NH2 dihydrochloride, (S,R,S)-AHPC-C6-NH2 dihydrochlorideCas No. 2341796-77-6
(S, R, S)-AHPC-C6-NH2 dihydrochloride (also known as VH032-C6-NH2 dihydrochloride) is a synthesized compound that functions as a ligand-linker conjugate for E3 ligase. It incorporates the VH032-based VHL ligand along with a linker, which is used for the degradation of AKT PROTAC.
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25 mg$85835 days35 days
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Product Introduction

Bioactivity
Description
(S, R, S)-AHPC-C6-NH2 dihydrochloride (also known as VH032-C6-NH2 dihydrochloride) is a synthesized compound that functions as a ligand-linker conjugate for E3 ligase. It incorporates the VH032-based VHL ligand along with a linker, which is used for the degradation of AKT PROTAC.
In vitro
PROTACs consist of two distinct ligands linked together: one binds to an E3 ubiquitin ligase, and the other targets a specific protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
SynonymsVH032-C6-NH2 dihydrochloride, (S,R,S)-AHPC-C6-NH2 dihydrochloride
Chemical Properties
Molecular Weight594.21
FormulaC29H44ClN5O4S
Cas No.2341796-77-6
SmilesC([C@@H](NC(CCCCCCN)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1.Cl.Cl
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

VH032-C6-NH2 DihydrochlorideVH032-C6-NH2AHPC-C6-NH2 DihydrochlorideAHPC-C6-NH2(S,R,S)-AHPC-C-6-NH2 dihydrochloride(S,R,S)AHPCC6NH2 dihydrochloride(S,R,S) AHPC C6 NH2 dihydrochloride
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