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ODN 2216
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Catalog No. T64280Cas No. 332437-00-0
Alias ODN-2216, ODN2216
ODN 2216 is a human-specific Toll-like receptor 9 agonist that induces robust production of interferon-α and interferon-β, activates plasmacytoid dendritic cells and conventional dendritic cells to produce IL-12. ODN 2216 indirectly stimulates IFN-γ release in peripheral blood mononuclear cells, and enhances NK cell and TCR-triggered CD4+ T-cell responses for immunological research.
ODN 2216
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Catalog No. T64280Alias ODN-2216, ODN2216Cas No. 332437-00-0
ODN 2216 is a human-specific Toll-like receptor 9 agonist that induces robust production of interferon-α and interferon-β, activates plasmacytoid dendritic cells and conventional dendritic cells to produce IL-12. ODN 2216 indirectly stimulates IFN-γ release in peripheral blood mononuclear cells, and enhances NK cell and TCR-triggered CD4+ T-cell responses for immunological research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $67 | 2-4 weeks | 2-4 weeks | |
| 5 mg | $175 | 2-4 weeks | 2-4 weeks | |
| 10 mg | $281 | 2-4 weeks | 2-4 weeks | |
| 25 mg | $683 | 2-4 weeks | 2-4 weeks | |
| 50 mg | $900 | 2-4 weeks | 2-4 weeks | |
| 100 mg | $1,450 | 2-4 weeks | 2-4 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | ODN 2216 is a human-specific Toll-like receptor 9 agonist that induces robust production of interferon-α and interferon-β, activates plasmacytoid dendritic cells and conventional dendritic cells to produce IL-12. ODN 2216 indirectly stimulates IFN-γ release in peripheral blood mononuclear cells, and enhances NK cell and TCR-triggered CD4+ T-cell responses for immunological research. |
| In vitro | In immunological assays, co-culture of naive CD4+ T cells with ODN 2216 (6 μg/mL) for 9 days drove differentiation into Th1 effector cells via an IFN-α/IL-12-dependent mechanism. Additionally, treatment of thymic dendritic cells with 2 μM of the compound for 15 hours reduced spontaneous apoptosis rates to 23.1% compared to controls [1]. |
| In vivo | In mouse models, ODN 2216 is used as an immunoadjuvant to elicit T-cell mediated antitumor immune responses. In liver disease research, the agonist has been employed to study the mtDNA/TLR9/MicroRNA-223 negative feedback loop. This signaling axis regulates neutrophil activation and provides protection against acetaminophen-induced hepatotoxicity in experimental animal models [3][4] |
| Synonyms | ODN-2216, ODN2216 |
| Cas No. | 332437-00-0 |
| Sequence | DNA, d(G-sp-G-sp-G-G-G-A-C-G-A-T-C-G-T-C-G-sp-G-sp-G-sp-G-sp-G-sp-G) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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