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ODN 2216
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Catalog No. T64280Cas No. 332437-00-0
Alias ODN-2216, ODN2216
ODN 2216 is a human-specific Toll-like receptor 9 agonist that induces robust production of interferon-α and interferon-β, activates plasmacytoid dendritic cells and conventional dendritic cells to produce IL-12. ODN 2216 indirectly stimulates IFN-γ release in peripheral blood mononuclear cells, and enhances NK cell and TCR-triggered CD4+ T-cell responses for immunological research.
ODN 2216
😃Good
Catalog No. T64280Alias ODN-2216, ODN2216Cas No. 332437-00-0
ODN 2216 is a human-specific Toll-like receptor 9 agonist that induces robust production of interferon-α and interferon-β, activates plasmacytoid dendritic cells and conventional dendritic cells to produce IL-12. ODN 2216 indirectly stimulates IFN-γ release in peripheral blood mononuclear cells, and enhances NK cell and TCR-triggered CD4+ T-cell responses for immunological research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $67 | 2-4 weeks | 2-4 weeks | |
| 5 mg | $175 | 2-4 weeks | 2-4 weeks | |
| 10 mg | $281 | 2-4 weeks | 2-4 weeks | |
| 25 mg | $683 | 2-4 weeks | 2-4 weeks | |
| 50 mg | $900 | 2-4 weeks | 2-4 weeks | |
| 100 mg | $1,450 | 2-4 weeks | 2-4 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | ODN 2216 is a human-specific Toll-like receptor 9 agonist that induces robust production of interferon-α and interferon-β, activates plasmacytoid dendritic cells and conventional dendritic cells to produce IL-12. ODN 2216 indirectly stimulates IFN-γ release in peripheral blood mononuclear cells, and enhances NK cell and TCR-triggered CD4+ T-cell responses for immunological research. |
| In vitro | In immunological assays, co-culture of naive CD4+ T cells with ODN 2216 (6 μg/mL) for 9 days drove differentiation into Th1 effector cells via an IFN-α/IL-12-dependent mechanism. Additionally, treatment of thymic dendritic cells with 2 μM of the compound for 15 hours reduced spontaneous apoptosis rates to 23.1% compared to controls [1]. |
| In vivo | In mouse models, ODN 2216 is used as an immunoadjuvant to elicit T-cell mediated antitumor immune responses. In liver disease research, the agonist has been employed to study the mtDNA/TLR9/MicroRNA-223 negative feedback loop. This signaling axis regulates neutrophil activation and provides protection against acetaminophen-induced hepatotoxicity in experimental animal models [3][4] |
| Synonyms | ODN-2216, ODN2216 |
| Cas No. | 332437-00-0 |
| Sequence | DNA, d(G-sp-G-sp-G-G-G-A-C-G-A-T-C-G-T-C-G-sp-G-sp-G-sp-G-sp-G-sp-G) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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