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SpiD3
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Catalog No. T88296Cas No. 3033533-25-1
Alias SpiD 3
SpiD3 is an antitumor spirocyclic dimer with the advantage of being independent of TME (tumor microenvironment) stimulation. It induces apoptosis in chronic lymphocytic leukemia (CLL) cells, inhibits NF-κB activation, upregulates the UPR (unfolded protein response), and suppresses protein synthesis. It can be used to study BTK-mutated CLL.
SpiD3
😃Good
Purity: 99.15%
Catalog No. T88296Alias SpiD 3Cas No. 3033533-25-1
SpiD3 is an antitumor spirocyclic dimer with the advantage of being independent of TME (tumor microenvironment) stimulation. It induces apoptosis in chronic lymphocytic leukemia (CLL) cells, inhibits NF-κB activation, upregulates the UPR (unfolded protein response), and suppresses protein synthesis. It can be used to study BTK-mutated CLL.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $52 | - | In Stock | |
| 5 mg | $123 | - | In Stock | |
| 10 mg | $197 | - | In Stock | |
| 25 mg | $396 | - | In Stock | |
| 50 mg | $637 | - | In Stock | |
| 100 mg | $987 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.15%
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Product Introduction
Bioactivity
Chemical Properties
| Description | SpiD3 is an antitumor spirocyclic dimer with the advantage of being independent of TME (tumor microenvironment) stimulation. It induces apoptosis in chronic lymphocytic leukemia (CLL) cells, inhibits NF-κB activation, upregulates the UPR (unfolded protein response), and suppresses protein synthesis. It can be used to study BTK-mutated CLL. |
| In vitro | SpiD3 (0.01–100 µM; 72 hours) exhibits antiproliferative properties in chronic lymphocytic leukemia (CLL) cell lines [1]. SpiD3 (0.25–1 µM) induced apoptosis in CLL cell lines after 24 hours of treatment and caused CLL cells to accumulate in the G0–G1 phase after 48 hours, with a corresponding decrease in the number of cells in the G2–M phase [1]. SpiD3 (0.5–2 µM; 4 h) induces the unfolded protein response (UPR) and inhibits protein translation in chronic lymphocytic leukemia (CLL) cells [1]. |
| In vivo | Methods: SpiD3_AP (a dimethylamino prodrug of SpiD3) was administered at 10 mg/kg to Eµ-TCL1 transgenic leukemia mice via daily intravenous injection for 3 days. Results: SpiD3_AP reduced tumor burden in Eµ-TCL1 mice, with significant downregulation of oncogenic MYC protein expression [1]. |
| Synonyms | SpiD 3 |
| Molecular Weight | 470.47 |
| Formula | C27H22N2O6 |
| Cas No. | 3033533-25-1 |
| Smiles | O=C1OC2(C(=O)N(C=3C=CC=CC32)CCCN4C(=O)C5(OC(=O)C(=C)C5)C=6C=CC=CC64)CC1=C |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (42.51 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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