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SpiD3
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Catalog No. T88296Cas No. 3033533-25-1
Alias SpiD 3
SpiD3 is an antitumor spirocyclic dimer with the advantage of being independent of TME (tumor microenvironment) stimulation. It induces apoptosis in chronic lymphocytic leukemia (CLL) cells, inhibits NF-κB activation, upregulates the UPR (unfolded protein response), and suppresses protein synthesis. It can be used to study BTK-mutated CLL.
SpiD3
😃Good
Purity: 99.15%
Catalog No. T88296Alias SpiD 3Cas No. 3033533-25-1
SpiD3 is an antitumor spirocyclic dimer with the advantage of being independent of TME (tumor microenvironment) stimulation. It induces apoptosis in chronic lymphocytic leukemia (CLL) cells, inhibits NF-κB activation, upregulates the UPR (unfolded protein response), and suppresses protein synthesis. It can be used to study BTK-mutated CLL.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $52 | - | In Stock | |
| 5 mg | $123 | - | In Stock | |
| 10 mg | $197 | - | In Stock | |
| 25 mg | $396 | - | In Stock | |
| 50 mg | $637 | - | In Stock | |
| 100 mg | $987 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.15%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SpiD3 is an antitumor spirocyclic dimer with the advantage of being independent of TME (tumor microenvironment) stimulation. It induces apoptosis in chronic lymphocytic leukemia (CLL) cells, inhibits NF-κB activation, upregulates the UPR (unfolded protein response), and suppresses protein synthesis. It can be used to study BTK-mutated CLL. |
| In vitro | SpiD3 (0.01–100 µM; 72 hours) exhibits antiproliferative properties in chronic lymphocytic leukemia (CLL) cell lines [1]. SpiD3 (0.25–1 µM) induced apoptosis in CLL cell lines after 24 hours of treatment and caused CLL cells to accumulate in the G0–G1 phase after 48 hours, with a corresponding decrease in the number of cells in the G2–M phase [1]. SpiD3 (0.5–2 µM; 4 h) induces the unfolded protein response (UPR) and inhibits protein translation in chronic lymphocytic leukemia (CLL) cells [1]. |
| In vivo | Methods: SpiD3_AP (a dimethylamino prodrug of SpiD3) was administered at 10 mg/kg to Eµ-TCL1 transgenic leukemia mice via daily intravenous injection for 3 days. Results: SpiD3_AP reduced tumor burden in Eµ-TCL1 mice, with significant downregulation of oncogenic MYC protein expression [1]. |
| Synonyms | SpiD 3 |
| Molecular Weight | 470.47 |
| Formula | C27H22N2O6 |
| Cas No. | 3033533-25-1 |
| Smiles | O=C1OC2(C(=O)N(C=3C=CC=CC32)CCCN4C(=O)C5(OC(=O)C(=C)C5)C=6C=CC=CC64)CC1=C |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (42.51 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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