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TP0427736

Name: TP0427736
Brand: TargetMol
SKU: T24897
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T24897Cas No. 864374-00-5

Alias TP-427736, TP427736, TP-0427736

TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.

TP0427736

🥰Excellent

Purity: 97.26%

Catalog No. T24897Alias TP-427736, TP427736, TP-0427736Cas No. 864374-00-5

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$238	In Stock
10 mg	$389	In Stock
25 mg	$663	In Stock
50 mg	$945	In Stock
1 mL x 10 mM (in DMSO)	$269	In Stock

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Batch Information

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Purity:97.26%

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COA LCMS

Product Introduction

Bioactivity

Description	TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
Targets&IC50	ALK5:2.72 nM
Synonyms	TP-427736, TP427736, TP-0427736

Chemical Properties

Molecular Weight	298.39
Formula	C₁₄H₁₀N₄S₂
Cas No.	864374-00-5
Smiles	CC=1N=C(C2=C(NC=N2)C=3C=C4C(=CC3)N=CS4)SC1
Relative Density.	1.439 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (217.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3513 mL	16.7566 mL	33.5132 mL	167.5659 mL
5 mM	0.6703 mL	3.3513 mL	6.7026 mL	33.5132 mL
10 mM	0.3351 mL	1.6757 mL	3.3513 mL	16.7566 mL
20 mM	0.1676 mL	0.8378 mL	1.6757 mL	8.3783 mL
50 mM	0.0670 mL	0.3351 mL	0.6703 mL	3.3513 mL
100 mM	0.0335 mL	0.1676 mL	0.3351 mL	1.6757 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc