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TP0427736
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Catalog No. T24897Cas No. 864374-00-5
Alias TP-427736, TP427736, TP-0427736
TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
TP0427736
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Purity: 97.26%
Catalog No. T24897Alias TP-427736, TP427736, TP-0427736Cas No. 864374-00-5
TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $97 | In Stock | In Stock | |
| 5 mg | $238 | In Stock | In Stock | |
| 10 mg | $389 | In Stock | In Stock | |
| 25 mg | $663 | In Stock | In Stock | |
| 50 mg | $945 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $269 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:97.26%
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Product Introduction
TP0427736 AI Summary
TP0427736 has demonstrated significant bioactivity, including a high solubility of 14,900.0 µg/mL. It acts as an inhibitor in various assays with notable potency: it inhibits ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation with an IC50 of 8.7 nM, and it inhibits human ALK5 using GST-tagged Smad3 as a substrate with an IC50 of 2.7 nM. Additionally, it inhibits human GST-tagged TGFbeta 1 using 3,3',5,5'-tetramethylbenzidine as a substrate, with an IC50 of 2.72 nM when incubated for 30 minutes in the presence of ATP. Moreover, it shows inhibitory activity against human GST-tagged ALK3 with an IC50 value of 836.0 nM, also following a 30-minute incubation with ATP by the QSSA Kit method..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles. |
| Targets&IC50 | ALK5:2.72 nM |
| Synonyms | TP-427736, TP427736, TP-0427736 |
| Molecular Weight | 298.39 |
| Formula | C14H10N4S2 |
| Cas No. | 864374-00-5 |
| Smiles | CC=1N=C(C2=C(NC=N2)C=3C=C4C(=CC3)N=CS4)SC1 |
| Relative Density. | 1.439 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 65 mg/mL (217.84 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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