Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nrf2-IN-3 (Compound R16), a Nrf2 inhibitor, binds to KEAP1 mutants (G333C mKEAP1) thereby restoring the impaired KEAP1/NRF2 interactions. This restoration sensitizes KEAP1-mutant cancer cells to chemotherapeutic agents, such as Cisplatin and Gefitinib, by reestablishing the functionality of the mKEAP1/NRF2 complex [1].
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Description | Nrf2-IN-3 (Compound R16), a Nrf2 inhibitor, binds to KEAP1 mutants (G333C mKEAP1) thereby restoring the impaired KEAP1/NRF2 interactions. This restoration sensitizes KEAP1-mutant cancer cells to chemotherapeutic agents, such as Cisplatin and Gefitinib, by reestablishing the functionality of the mKEAP1/NRF2 complex [1]. |
Molecular Weight | 442.53 |
Formula | C22H26N4O4S |
CAS No. | 6325-13-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Nrf2-IN-3 6325-13-9 inhibitor inhibit