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7-FluorotryptaMine HCl

Name: 7-FluorotryptaMine HCl
Brand: TargetMol
SKU: T77673
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77673Cas No. 159730-09-3

7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.

7-FluorotryptaMine HCl

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Purity: 98.06%

Catalog No. T77673Cas No. 159730-09-3

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$37	-	In Stock
5 mg	$64	-	In Stock
10 mg	$105	-	In Stock
25 mg	$222	-	In Stock
50 mg	$333	-	In Stock
1 mL x 10 mM (in DMSO)	$60	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.06%

Appearance:Solid

Color:Blue

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.
In vitro	In the PRESTO-Tango assay, 7-FluorotryptaMine HCl (100 μM) hydrochloride induces GPRC5A recruitment of β-arrestin.[1] Co-treatment with 7-FluorotryptaMine HCl (50 μM, 8 h) and TNFα downregulates TNFα-induced genes (e.g., IL41A, CXCL10, CSF2) in WT and GPRC5A-KO cells [1]. 7-FluorotryptaMine HCl (0-100 μM, 16 h) is not toxic to mammalian cells (HTLA, HT-29 cells).[1]

Chemical Properties

Molecular Weight	214.67
Formula	C₁₀H₁₂ClFN₂
Cas No.	159730-09-3
Smiles	Cl.FC1=CC=CC=2C(=CNC12)CCN

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 21.47 mg/mL (100.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6583 mL	23.2916 mL	46.5831 mL	232.9156 mL
5 mM	0.9317 mL	4.6583 mL	9.3166 mL	46.5831 mL
10 mM	0.4658 mL	2.3292 mL	4.6583 mL	23.2916 mL
20 mM	0.2329 mL	1.1646 mL	2.3292 mL	11.6458 mL
50 mM	0.0932 mL	0.4658 mL	0.9317 mL	4.6583 mL
100 mM	0.0466 mL	0.2329 mL	0.4658 mL	2.3292 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc