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7-FluorotryptaMine HCl

🥰Excellent
Catalog No. T77673Cas No. 159730-09-3

7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.

7-FluorotryptaMine HCl

7-FluorotryptaMine HCl

🥰Excellent
Purity: 98.06%
Catalog No. T77673Cas No. 159730-09-3
7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.
Pack SizePriceAvailabilityQuantity
2 mg$37In Stock
5 mg$64In Stock
10 mg$105In Stock
25 mg$222In Stock
50 mg$333In Stock
1 mL x 10 mM (in DMSO)$60In Stock
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Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.06%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.
In vitro
In the PRESTO-Tango assay, 7-FluorotryptaMine HCl (100 μM) hydrochloride induces GPRC5A recruitment of β-arrestin.[1]
Co-treatment with 7-FluorotryptaMine HCl (50 μM, 8 h) and TNFα downregulates TNFα-induced genes (e.g., IL41A, CXCL10, CSF2) in WT and GPRC5A-KO cells [1].
7-FluorotryptaMine HCl (0-100 μM, 16 h) is not toxic to mammalian cells (HTLA, HT-29 cells).[1]
Chemical Properties
Molecular Weight214.67
FormulaC10H12ClFN2
Cas No.159730-09-3
SmilesCl.FC1=CC=CC=2C(=CNC12)CCN
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 21.47 mg/mL (100 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.6583 mL23.2916 mL46.5831 mL232.9156 mL
5 mM0.9317 mL4.6583 mL9.3166 mL46.5831 mL
10 mM0.4658 mL2.3292 mL4.6583 mL23.2916 mL
20 mM0.2329 mL1.1646 mL2.3292 mL11.6458 mL
50 mM0.0932 mL0.4658 mL0.9317 mL4.6583 mL
100 mM0.0466 mL0.2329 mL0.4658 mL2.3292 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

GPRC5A7FluorotryptaMineHCl7-FluorotryptaMine HCl
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