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TS-24

Name: TS-24
Brand: TargetMol
SKU: T85311
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T85311Cas No. 1563260-97-8

Alias TS24, TS 24

TS-24 is an inhibitor of the cysteine protease histatin S (CTSS).TS-24 promotes BRCA1-mediated apoptosis and shows radiosensitization in a TNBC xenograft mouse model.

TS-24

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Purity: 99.41%

Catalog No. T85311Alias TS24, TS 24Cas No. 1563260-97-8

TS-24 is an inhibitor of the cysteine protease histatin S (CTSS).TS-24 promotes BRCA1-mediated apoptosis and shows radiosensitization in a TNBC xenograft mouse model.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	-	In Stock
5 mg	$91	-	In Stock
10 mg	$146	-	In Stock
25 mg	$293	-	In Stock
50 mg	$472	-	In Stock
100 mg	$756	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.41%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	TS-24 is an inhibitor of the cysteine protease histatin S (CTSS).TS-24 promotes BRCA1-mediated apoptosis and shows radiosensitization in a TNBC xenograft mouse model.
Targets&IC50	cathepsin S:4.3 μM
In vitro	In MDA-MB-231 cells, TS-24 (0-10 μM; 24 hours) can inhibit cell migration[1].
Synonyms	TS24, TS 24

Chemical Properties

Molecular Weight	301.34
Formula	C₂₀H₁₅NO₂
Cas No.	1563260-97-8
Smiles	O=C(C=CC1=CN(C=2C=CC=CC12)C)C=3OC=4C=CC=CC4C3
Relative Density.	1.18 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (99.56 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3185 mL	16.5926 mL	33.1851 mL	165.9255 mL
5 mM	0.6637 mL	3.3185 mL	6.6370 mL	33.1851 mL
10 mM	0.3319 mL	1.6593 mL	3.3185 mL	16.5926 mL
20 mM	0.1659 mL	0.8296 mL	1.6593 mL	8.2963 mL
50 mM	0.0664 mL	0.3319 mL	0.6637 mL	3.3185 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc