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Ch55

Name: Ch55
Brand: TargetMol
SKU: T14946
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14946Cas No. 110368-33-7

Alias Ch-55, CH 55, 3,5-Di-tert-butylchalcone

Ch55 (3,5-Di-tert-butylchalcone) is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer.

Ch55

🥰Excellent

Purity: 99.55%

Catalog No. T14946Alias Ch-55, CH 55, 3,5-Di-tert-butylchalconeCas No. 110368-33-7

Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$79	In Stock
10 mg	$126	In Stock
25 mg	$267	In Stock
50 mg	$415	In Stock
100 mg	$645	In Stock
200 mg	$887	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock

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Purity:99.55%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ch55 (3,5-Di-tert-butylchalcone) is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer.
In vitro	In rabbit tracheal epithelial cells, Ch55 inhibits type I transglutaminase activity (EC50 = 0.02 nM) and increases cholesterol sulfate levels (EC50 = 0.03 nM) thereby inhibiting squamous cell differentiation. Ch55 inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM) and induces cell differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50 = 0.26 and 0.5 nM). Ch55 shows a low affinity for cellular retinoic acid binding protein[1].
Synonyms	Ch-55, CH 55, 3,5-Di-tert-butylchalcone

Chemical Properties

Molecular Weight	364.48
Formula	C₂₄H₂₈O₃
Cas No.	110368-33-7
Smiles	CC(C)(C)c1cc(cc(c1)C(C)(C)C)C(=O)\C=C\c1ccc(cc1)C(O)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (109.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7436 mL	13.7182 mL	27.4363 mL	137.1817 mL
5 mM	0.5487 mL	2.7436 mL	5.4873 mL	27.4363 mL
10 mM	0.2744 mL	1.3718 mL	2.7436 mL	13.7182 mL
20 mM	0.1372 mL	0.6859 mL	1.3718 mL	6.8591 mL
50 mM	0.0549 mL	0.2744 mL	0.5487 mL	2.7436 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3718 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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