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KTC1101

Name: KTC1101
Brand: TargetMol
SKU: T89831
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T89831Cas No. 2764833-47-6

Alias KTC 1101

KTC1101 is an oral-active, pan-PI3K inhibitor targeting tumor cell proliferation and tumor microenvironment, with anti-proliferative and anti-tumor activity, reducing downstream AKT and mTOR phosphorylation.

KTC1101

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Purity: 98.75%

Catalog No. T89831Alias KTC 1101Cas No. 2764833-47-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	-	In Stock
5 mg	$160	-	In Stock
10 mg	$260	-	In Stock
25 mg	$522	-	In Stock
50 mg	$843	-	In Stock
100 mg	$1,350	-	In Stock
1 mL x 10 mM (in DMSO)	$160	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.75%

Appearance:Solid

Color:Gray

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	KTC1101 is an oral-active, pan-PI3K inhibitor targeting tumor cell proliferation and tumor microenvironment, with anti-proliferative and anti-tumor activity, reducing downstream AKT and mTOR phosphorylation.
Targets&IC50	PI3Kγ:17.09 nM, PI3Kβ:36.29 nM, PI3Kδ:1.22 nM, PI3Kα:3.72 nM
In vitro	The IC50 values of KTC1101 for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ were 3.72 nM, 36.29 nM, 1.22 nM and 17.09 nM, respectively. KTC1101 effectively inhibited the PI3K signaling pathway, and the phosphorylation of PI3K downstream effector AKT and mTOR was decreased. [1]
In vivo	In mice, KTC1101 (100 mg/kg) has good oral effect, Tmax is 0.67 h, Cmax is 1.66 μg/mL, AUC0-t is 9.33 μg/mL*h. KTC1101 (100 mg/kg) showed favorable tumor inhibition in mice in four tumor models tested (PC3, CAL33, and HSC2). [1]
Synonyms	KTC 1101

Chemical Properties

Molecular Weight	476.48
Formula	C₂₁H₂₆F₂N₈O₃
Cas No.	2764833-47-6
Smiles	FC(F)C1=NC=2C(OC)=CC(N)=CC2N1C=3N=C(N=C(N3)N4CCOCCC4)N5CCOCC5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (41.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0987 mL	10.4936 mL	20.9872 mL	104.9362 mL
5 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9872 mL
10 mM	0.2099 mL	1.0494 mL	2.0987 mL	10.4936 mL
20 mM	0.1049 mL	0.5247 mL	1.0494 mL	5.2468 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc