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CAL-130 Hydrochloride

Name: CAL-130 Hydrochloride
Brand: TargetMol
SKU: T10660L
Rating: 4.5 (1 reviews)

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Catalog No. T10660LCas No. 1431697-78-7

CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).

CAL-130 Hydrochloride

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Catalog No. T10660LCas No. 1431697-78-7

CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$127	5 days	5 days
5 mg	$249	5 days	5 days
25 mg	$763	6-8 weeks	6-8 weeks
50 mg	$992	6-8 weeks	6-8 weeks
100 mg	$1,490	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$287	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
Targets&IC50	p110β:56 nM, p110δ:1.3 nM, p110α:115 nM, p110γ:6.1 nM
In vitro	CAL-130 selectively inhibits the catalytic domains of p110γ and p110δ with IC50s of 1.3 and 6.1 nM, respectively (115 and 56 nM for p110α and p110β), and does not affect other intracellular signaling pathways essential for cell function and survival, such as p38 MAPK or insulin receptor tyrosine kinase.
In vivo	The clinical significance of inhibiting PI3Kγ and PI3Kδ activities is assessed by administering CAL-130 to Lck/Ptenfl/fl mice with established T cell acute lymphoblastic leukemia. Candidate mice, exhibiting illness, a white blood cell count above 45,000/μL, blasts on peripheral smear, and >75% Thy1.2 and Ki-67 double-positive circulating cells, receive an oral dose (10 mg/kg) of CAL-130 every 8 hours for 7 days and are monitored until moribund. Despite the limited duration of therapy, CAL-130 effectively extends median survival to 45 days compared to 7.5 days for the control group.

Chemical Properties

Molecular Weight	462.94
Formula	C₂₃H₂₃ClN₈O
Cas No.	1431697-78-7
Smiles	Cl.C[C@H](Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)c2c(=O)n1-c1ccccc1C
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (108.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1601 mL	10.8005 mL	21.6011 mL	108.0054 mL
5 mM	0.4320 mL	2.1601 mL	4.3202 mL	21.6011 mL
10 mM	0.2160 mL	1.0801 mL	2.1601 mL	10.8005 mL
20 mM	0.1080 mL	0.5400 mL	1.0801 mL	5.4003 mL
50 mM	0.0432 mL	0.2160 mL	0.4320 mL	2.1601 mL
100 mM	0.0216 mL	0.1080 mL	0.2160 mL	1.0801 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc