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Angoline hydrochloride
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Catalog No. T75672Cas No. 1071676-04-4
Alias 6-Methoxyldihydrochelerythrine
Angoline hydrochloride (6-Methoxyldihydrochelerythrine) is an IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum with anticancer activity and inhibits STAT3 signaling.
Angoline hydrochloride
🥰Excellent
Purity: 98.6%
Catalog No. T75672Alias 6-MethoxyldihydrochelerythrineCas No. 1071676-04-4
Angoline hydrochloride (6-Methoxyldihydrochelerythrine) is an IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum with anticancer activity and inhibits STAT3 signaling.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $44 | In Stock | |
| 5 mg | $97 | In Stock | |
| 10 mg | $142 | In Stock | |
| 25 mg | $264 | In Stock |
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Purity:98.6%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Angoline hydrochloride (6-Methoxyldihydrochelerythrine) is an IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum with anticancer activity and inhibits STAT3 signaling. |
| Targets&IC50 | STAT3:11.56 μM |
| In vitro | Angoline hydrochloride acting in the range of 0 to 100 μM for 1 hr was able to inhibit STAT3, STAT1 and NF-κB signaling pathways with the IC50 of 11.56 μM, >100 μM and >100 μM, respectively. Angoline hydrochloride acted in the range of 0 to 100 μM for 2 hours and was able to affect the phosphorylation process of STAT3. Angoline hydrochloride acting in the range of 0 to 100 μM for 72 hours was able to inhibit the proliferation of MDA-MB-231, H4 and HepG2 cells. [1] |
| Synonyms | 6-Methoxyldihydrochelerythrine |
| Molecular Weight | 415.87 |
| Formula | C22H22ClNO5 |
| Cas No. | 1071676-04-4 |
| Smiles | Cl.O(C=1C=CC=2C3=CC=C4C=C5OCOC5=CC4=C3N(C)C(OC)C2C1OC)C |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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