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Angoline hydrochloride
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Catalog No. T75672Cas No. 1071676-04-4
Alias 6-Methoxyldihydrochelerythrine
Angoline hydrochloride (6-Methoxyldihydrochelerythrine) is an IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum with anticancer activity and inhibits STAT3 signaling.
Angoline hydrochloride
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Purity: 98.6%
Catalog No. T75672Alias 6-MethoxyldihydrochelerythrineCas No. 1071676-04-4
Angoline hydrochloride (6-Methoxyldihydrochelerythrine) is an IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum with anticancer activity and inhibits STAT3 signaling.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $40 | - | In Stock | |
| 2 mg | $59 | - | In Stock | |
| 5 mg | $97 | - | In Stock | |
| 10 mg | $142 | - | In Stock | |
| 25 mg | $263 | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.6%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Angoline hydrochloride (6-Methoxyldihydrochelerythrine) is an IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum with anticancer activity and inhibits STAT3 signaling. |
| Targets&IC50 | STAT3:11.56 μM |
| In vitro | Angoline hydrochloride acting in the range of 0 to 100 μM for 1 hr was able to inhibit STAT3, STAT1 and NF-κB signaling pathways with the IC50 of 11.56 μM, >100 μM and >100 μM, respectively. Angoline hydrochloride acted in the range of 0 to 100 μM for 2 hours and was able to affect the phosphorylation process of STAT3. Angoline hydrochloride acting in the range of 0 to 100 μM for 72 hours was able to inhibit the proliferation of MDA-MB-231, H4 and HepG2 cells. [1] |
| Synonyms | 6-Methoxyldihydrochelerythrine |
| Molecular Weight | 415.87 |
| Formula | C22H22ClNO5 |
| Cas No. | 1071676-04-4 |
| Smiles | Cl.O(C=1C=CC=2C3=CC=C4C=C5OCOC5=CC4=C3N(C)C(OC)C2C1OC)C |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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