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TG-46

Name: TG-46
Brand: TargetMol
SKU: T20743
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T20743Cas No. 936091-15-5

Alias TG46, TG 46

TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.

TG-46

🥰Excellent

Purity: 99.81%

Catalog No. T20743Alias TG46, TG 46Cas No. 936091-15-5

TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.

Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$430	In Stock
10 mg	$650	In Stock
25 mg	$1,110	In Stock
50 mg	$1,680	In Stock
100 mg	$2,540	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.81%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.
Synonyms	TG46, TG 46

Chemical Properties

Molecular Weight	510.65
Formula	C₂₆H₃₄N₆O₃S
Cas No.	936091-15-5
Smiles	Cc1cnc(Nc2ccc(CN3CCOCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (88.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9583 mL	9.7914 mL	19.5829 mL	97.9144 mL
5 mM	0.3917 mL	1.9583 mL	3.9166 mL	19.5829 mL
10 mM	0.1958 mL	0.9791 mL	1.9583 mL	9.7914 mL
20 mM	0.0979 mL	0.4896 mL	0.9791 mL	4.8957 mL
50 mM	0.0392 mL	0.1958 mL	0.3917 mL	1.9583 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc