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JAK-IN-21

Name: JAK-IN-21
Brand: TargetMol
SKU: T61494
Price: 90 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61494Cas No. 2445499-20-5

JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.

JAK-IN-21

🥰Excellent

Purity: 99.75%

Catalog No. T61494Cas No. 2445499-20-5

JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.

Pack Size	Price	Availability
1 mg	$90	In Stock
5 mg	$226	In Stock
10 mg	$345	In Stock
25 mg	$663	In Stock
50 mg	$826	In Stock
100 mg	$1,050	In Stock
200 mg	$1,380	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.
Targets&IC50	JAK2 (V617F):109 nM, JAK2:2.04 nM, TYK2:62.9 nM, JAK1:1.73 nM
In vitro	JAK-IN-21 (Example 4) exhibits no inhibitory effects on CYPs and shows favorable stability in liver microsomes.[1]
In vivo	JAK-IN-21 (Example 4) (10 mg/kg; Oral gavage; SD rats) demonstrates limited bioavailability, quantified at 1.9%.[1]

Chemical Properties

Molecular Weight	372.38
Formula	C₁₉H₁₆N₈O
Cas No.	2445499-20-5
Smiles	CC=1C(=NC(NC2=CN(CC#N)N=C2)=NC1)C3=CC=C(C(NCC#N)=O)C=C3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (161.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6854 mL	13.4271 mL	26.8543 mL	134.2714 mL
5 mM	0.5371 mL	2.6854 mL	5.3709 mL	26.8543 mL
10 mM	0.2685 mL	1.3427 mL	2.6854 mL	13.4271 mL
20 mM	0.1343 mL	0.6714 mL	1.3427 mL	6.7136 mL
50 mM	0.0537 mL	0.2685 mL	0.5371 mL	2.6854 mL
100 mM	0.0269 mL	0.1343 mL	0.2685 mL	1.3427 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc