store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 215.00 | |
2 mg | In stock | $ 318.00 | |
5 mg | In stock | $ 538.00 | |
10 mg | In stock | $ 823.00 | |
25 mg | In stock | $ 1,580.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 |
Description | JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively. |
Targets&IC50 | JAK1:1.73 nM, TYK2:62.9 nM, JAK2:2.04 nM, JAK2 (V617F):109 nM |
In vitro | JAK-IN-21 (Example 4) lacks inhibitory effects on CYPs and demonstrates favorable stability in liver microsomes.[1] |
In vivo | JAK-IN-21 (Example 4) (10 mg/kg; Oral gavage; SD rats) exhibits limited bioavailability with a value of 1.9%.[1] |
Molecular Weight | 372.38 |
Formula | C19H16N8O |
CAS No. | 2445499-20-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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JAK-IN-21 2445499-20-5 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells Tyrosine Kinase/Adaptors Tyrosine Kinases JAK inhibitor inhibit