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WCY-8-67 TFA

Name: WCY-8-67 TFA
Brand: TargetMol
SKU: T212843L
Rating: 4.5 (1 reviews)

Catalog No. T212843L Copy Product Info

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WCY-8-67 TFA is an orally bioavailable selective USP5 inhibitor with an IC₅₀ of 1.33 μM. It induces apoptosis in vitro and inhibits the JAK/STAT3 and PI3K/AKT signaling pathways. WCY-8-67 TFA suppresses the proliferation of AE-positive acute myeloid leukemia (AML) cells, induces G1 phase cell cycle arrest, and promotes cell differentiation. It shows significant anti-leukemic activity in mouse in vivo experiments and can be used in AML research.

WCY-8-67 TFA

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Catalog No. T212843L

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Product Introduction

Bioactivity

Description

Targets&IC50

USP5:1.33 μM

Chemical Properties

Molecular Weight	563.59
Formula	C₂₇H₃₃F₄N₇O₂
Smiles	FC1=CC=C(N2CC3=C(C2)C(N(CCN(C)C)C)=NC(N4CCNCC4)=N3)C5=C1C=CC=C5.OC(C(F)(F)F)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (141.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7743 mL	8.8717 mL	17.7434 mL	88.7170 mL
5 mM	0.3549 mL	1.7743 mL	3.5487 mL	17.7434 mL
10 mM	0.1774 mL	0.8872 mL	1.7743 mL	8.8717 mL
20 mM	0.0887 mL	0.4436 mL	0.8872 mL	4.4358 mL
50 mM	0.0355 mL	0.1774 mL	0.3549 mL	1.7743 mL
100 mM	0.0177 mL	0.0887 mL	0.1774 mL	0.8872 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

WCY867TFA（3052618546Freebase