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IGN523
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Catalog No. T9901A-1914
IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) that induces antibody-dependent cell-mediated cytotoxicity (ADCC). It permeabilizes lysosomal membranes and inhibits essential amino acid transport function, leading to caspase-3 and caspase-7 mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in various tumor xenograft models and can be used for research on cancers such as non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML).
IGN523
IGN523
😃Good
Catalog No. T9901A-1914
IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) that induces antibody-dependent cell-mediated cytotoxicity (ADCC). It permeabilizes lysosomal membranes and inhibits essential amino acid transport function, leading to caspase-3 and caspase-7 mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in various tumor xenograft models and can be used for research on cancers such as non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
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| Description | IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) that induces antibody-dependent cell-mediated cytotoxicity (ADCC). It permeabilizes lysosomal membranes and inhibits essential amino acid transport function, leading to caspase-3 and caspase-7 mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in various tumor xenograft models and can be used for research on cancers such as non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML). |
| In vitro | IGN523 strongly induces ADCC activity in Ramos, KG-1, and OCI-AML-3 cells with EC50 values of 18.6 ng/mL, 73.8 ng/mL, and 83.3 ng/mL, respectively, without diminishing ADCC activity within IGN523 cells. Furthermore, IGN523 (2 µg/mL, 0.5-48 hours) triggers caspase-dependent apoptosis, enhances lysosomal membrane permeability, and reduces amino acid transport in these cell lines. |
| In vivo | IGN523 (15 mg/kg, intraperitoneal injection, weekly, administered either two or three times) is effective in inhibiting tumor growth in Ramos and Dau xenograft mouse models. Furthermore, IGN523 (15 mg/kg, intraperitoneal injection, weekly, administered two, three, or four times) suppresses tumor growth in AML and primary NSCLC xenograft mouse models. |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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