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IGN523

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Catalog No. T9901A-1914

IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) that induces antibody-dependent cell-mediated cytotoxicity (ADCC). It permeabilizes lysosomal membranes and inhibits essential amino acid transport function, leading to caspase-3 and caspase-7 mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in various tumor xenograft models and can be used for research on cancers such as non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML).

IGN523

IGN523

😃Good
Catalog No. T9901A-1914
IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) that induces antibody-dependent cell-mediated cytotoxicity (ADCC). It permeabilizes lysosomal membranes and inhibits essential amino acid transport function, leading to caspase-3 and caspase-7 mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in various tumor xenograft models and can be used for research on cancers such as non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML).
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Product Introduction

Bioactivity
Description
IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) that induces antibody-dependent cell-mediated cytotoxicity (ADCC). It permeabilizes lysosomal membranes and inhibits essential amino acid transport function, leading to caspase-3 and caspase-7 mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in various tumor xenograft models and can be used for research on cancers such as non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML).
In vitro
IGN523 strongly induces ADCC activity in Ramos, KG-1, and OCI-AML-3 cells with EC50 values of 18.6 ng/mL, 73.8 ng/mL, and 83.3 ng/mL, respectively, without diminishing ADCC activity within IGN523 cells. Furthermore, IGN523 (2 µg/mL, 0.5-48 hours) triggers caspase-dependent apoptosis, enhances lysosomal membrane permeability, and reduces amino acid transport in these cell lines.
In vivo
IGN523 (15 mg/kg, intraperitoneal injection, weekly, administered either two or three times) is effective in inhibiting tumor growth in Ramos and Dau xenograft mouse models. Furthermore, IGN523 (15 mg/kg, intraperitoneal injection, weekly, administered two, three, or four times) suppresses tumor growth in AML and primary NSCLC xenograft mouse models.
Chemical Properties
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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