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IGN523
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Catalog No. T9901A-1914 Copy Product Info
Purity: 95%
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IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) that induces antibody-dependent cell-mediated cytotoxicity (ADCC). It permeabilizes lysosomal membranes and inhibits essential amino acid transport function, leading to caspase-3 and caspase-7 mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in various tumor xenograft models and can be used for research on cancers such as non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML).
IGN523
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $289 | - | In Stock | |
| 5 mg | $868 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95%
Appearance:Liquid
Color:Transparent
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| Description | IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) that induces antibody-dependent cell-mediated cytotoxicity (ADCC). It permeabilizes lysosomal membranes and inhibits essential amino acid transport function, leading to caspase-3 and caspase-7 mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in various tumor xenograft models and can be used for research on cancers such as non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML). |
| In vitro | IGN523 strongly induces ADCC activity in Ramos, KG-1, and OCI-AML-3 cells with EC50 values of 18.6 ng/mL, 73.8 ng/mL, and 83.3 ng/mL, respectively, without diminishing ADCC activity within IGN523 cells. Furthermore, IGN523 (2 µg/mL, 0.5-48 hours) triggers caspase-dependent apoptosis, enhances lysosomal membrane permeability, and reduces amino acid transport in these cell lines. |
| In vivo | IGN523 (15 mg/kg, intraperitoneal injection, weekly, administered either two or three times) is effective in inhibiting tumor growth in Ramos and Dau xenograft mouse models. Furthermore, IGN523 (15 mg/kg, intraperitoneal injection, weekly, administered two, three, or four times) suppresses tumor growth in AML and primary NSCLC xenograft mouse models. |
| Storage | Store at low temperature, -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: IGN523 in vivo | IGN523 in vitro
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