Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and <20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 105.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 497.00 | |
100 mg | In stock | $ 813.00 | |
500 mg | In stock | $ 1,630.00 |
Description | GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM). |
In vitro | GRP78-IN-3 (0.1-100 μM) shows more potent inhibition efffects in a spheroid tumor model (U251 glioblastoma cells and H520 lung cancer cells) [1]. |
Molecular Weight | 342.42 |
Formula | C17H18N4O2S |
CAS No. | 2707510-30-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. More
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GRP78-IN-3 2707510-30-1 Cytoskeletal Signaling Metabolism HSP GRP78IN3 inhibitor inhibit